过去30年蛋白质设计的关键方面

IF 19 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY
Giulia Magi Meconi, I. R. Sasselli, V. Bianco, J. Onuchic, I. Coluzza
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引用次数: 4

摘要

蛋白质是生命的主力。它们是生命系统的基础设施;它们是已知的最有效的分子机器,它们的酶活性在多功能性方面仍然是任何人工系统无法比拟的。也许蛋白质最显著的特征是它们的模块化。指定每种蛋白质功能所需的大量信息用仅约20个字母的字母表进行类比编码。蛋白质折叠的问题是如何将所有这些信息编码成20个字母的序列。在这篇综述中,我们回顾了近30年来的研究现状,并重点介绍了与蛋白质进化基本问题相关的一些应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Key aspects of the past 30 years of protein design
Proteins are the workhorse of life. They are the building infrastructure of living systems; they are the most efficient molecular machines known, and their enzymatic activity is still unmatched in versatility by any artificial system. Perhaps proteins’ most remarkable feature is their modularity. The large amount of information required to specify each protein’s function is analogically encoded with an alphabet of just ∼20 letters. The protein folding problem is how to encode all such information in a sequence of 20 letters. In this review, we go through the last 30 years of research to summarize the state of the art and highlight some applications related to fundamental problems of protein evolution.
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来源期刊
Reports on Progress in Physics
Reports on Progress in Physics 物理-物理:综合
CiteScore
31.90
自引率
0.00%
发文量
45
审稿时长
6-12 weeks
期刊介绍: Reports on Progress in Physics is a highly selective journal with a mission to publish ground-breaking new research and authoritative invited reviews of the highest quality and significance across all areas of physics and related areas. Articles must be essential reading for specialists, and likely to be of broader multidisciplinary interest with the expectation for long-term scientific impact and influence on the current state and/or future direction of a field.
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