新诊断慢性淋巴细胞白血病(CLL)患者的COVID-19: 1例报告

Alireza Gandomi-Mohammadabadi, Farshad Divsalar, S. Taram, Zahra Kateb, F. Montazer, Yasaman Farbod, Seyedamir Tabibzadeh Dezfooli, A. Abbasi, M. Abbasi
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引用次数: 0

摘要

慢性淋巴细胞白血病(CLL)是最常见的导致免疫抑制的血液肿瘤之一。它的特点是成熟B细胞的绝对淋巴细胞增多和克隆性。因此,他们很容易受到各种感染,特别是COVID-19。当COVID-19感染揭开CLL的面纱时,人们对它知之甚少。我们报告了一名90岁的男性,他表现出厌食、虚弱、意识丧失和淋巴细胞增多的体征和症状,并在进一步的COVID-19检查中通过实时PCR证实。由于淋巴细胞增多,行外周血涂片(PBS)和流式细胞术,诊断为CLL。住院期间淋巴细胞计数增加1.5倍。11天后,患者症状减轻,康复。在淋巴细胞中可能提示其他情况。在这些病例中,应考虑淋巴细胞增多的继发原因,如恶性肿瘤或其他感染
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COVID-19 in a Patient with Newly Diagnosed Chronic Lymphocytic Leukemia (CLL): A Case Report
Chronic lymphocytic leukemia (CLL) is one of the most common hematologic neoplasms leading to immunosuppression. It is characterized by absolute lymphocytosis with clonality of mature B cells. Therefore, they are vulnerable to various infections especially COVID-19. Little is known about the COVID-19 infection when it unmasks CLL. We reported a 90-year-old man who presented with signs and symptoms of anorexia, weakness, and loss of consciousness, and lymphocytosis which in further workup COVID-19 confirmed with real-time PCR. Due to lymphocytosis, peripheral blood smear (PBS) and flow cytometry were performed and CLL was diagnosed. His lymphocyte count increased to 1.5-fold during hospitalization. The patient recovered after 11 days as the symptoms were alleviated. in lymphocytes may indicate other conditions. In these cases, secondary causes of lymphocytosis, such as malignancy or other infections, should be considered
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