{"title":"生物活性物质和真菌来源的提取物","authors":"Hristova Dilyana, Rusinova-Videva Snezhana, Konstantinov Spiro","doi":"10.5530/PHREV.2021.15.2","DOIUrl":null,"url":null,"abstract":"Copyright © 2021 Phcog.Net. This is an openaccess article distributed under the terms of the Creative Commons Attribution 4.0 International license. ABSTRACT Studying the biological activity of fungi is crucial to discovering their potential for the treatment and prevention of various diseases. The diverse composition and various substances they produce are the basis of their application in medicine. Pullulan can be used as blood plasma substituent, carrier in drug delivery systems. Chitin possess antimicrobial, anticoagulant and antitumor activities. Inotodiol and the other substances from Inonotus obliquus possess strong cytotoxic activity against breast and gastric cancer. Camptothecin derivatives are used for treatment of ovarian and colorectal cancers. In our study we used a strain Antarctic yeasts Cryptococcus laurentii AL65. We found out that these psychrophilic yeasts possess antineoplastic activity. Their action is observed in solid tumors-bladder cancer. Along with their cytotoxic effects yeasts possess a very good safety profile and can be part of future antitumor therapy.","PeriodicalId":74432,"journal":{"name":"Pharmacognosy reviews","volume":"27 1","pages":"12-19"},"PeriodicalIF":0.0000,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Biologically Active Substances and Extracts of Fungal Origin\",\"authors\":\"Hristova Dilyana, Rusinova-Videva Snezhana, Konstantinov Spiro\",\"doi\":\"10.5530/PHREV.2021.15.2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Copyright © 2021 Phcog.Net. This is an openaccess article distributed under the terms of the Creative Commons Attribution 4.0 International license. ABSTRACT Studying the biological activity of fungi is crucial to discovering their potential for the treatment and prevention of various diseases. The diverse composition and various substances they produce are the basis of their application in medicine. Pullulan can be used as blood plasma substituent, carrier in drug delivery systems. Chitin possess antimicrobial, anticoagulant and antitumor activities. Inotodiol and the other substances from Inonotus obliquus possess strong cytotoxic activity against breast and gastric cancer. Camptothecin derivatives are used for treatment of ovarian and colorectal cancers. In our study we used a strain Antarctic yeasts Cryptococcus laurentii AL65. We found out that these psychrophilic yeasts possess antineoplastic activity. Their action is observed in solid tumors-bladder cancer. Along with their cytotoxic effects yeasts possess a very good safety profile and can be part of future antitumor therapy.\",\"PeriodicalId\":74432,\"journal\":{\"name\":\"Pharmacognosy reviews\",\"volume\":\"27 1\",\"pages\":\"12-19\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-06-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacognosy reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5530/PHREV.2021.15.2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacognosy reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5530/PHREV.2021.15.2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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