纳米混悬液:一种新的药物递送技术

Vidya Ashok Kheradkar, Jameel Ahmed S. Mulla
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引用次数: 0

摘要

纳米技术包括纳米悬浮液。纳米技术已经成为医学界的一个巨大领域。纳米混悬液是解决药物亲脂性、生物可利用性和难溶解性的一种很有前途的方法。最近开发的大多数药物的水溶性都很差。由于药物的水溶性有限,通常使药物配方复杂化。改善难溶性药物的溶解度有许多标准方法,包括介质研磨、均质化、沉淀技术等。利用纳米技术开发可降解药物制剂是药物开发的新途径。纳米技术中使用的颗粒尺寸从1纳米到1000纳米不等。由于药物颗粒尺寸减小到亚微米区域,溶解率的增加自然地提高了生物利用度。纳米混悬液技术是提高低水溶性药物溶出度的有效新方法。纳米混悬液通过解决亲脂性问题,如生物利用度和溶解性差,以及通过改变药代动力学,提高了药物的安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanosuspension: A Novel Technology for Drug Delivery
Nanotechnology includes nanosuspensions. Nanotechnology has become a huge area in the world of medicine. An appealing and promising approach to address the lipophilic like bio-available and poor solvability concerning the pharmaceuticals is nanosuspension. The majority of recently developed medications have poor water solubility. Drug formulation is usually complicated by medicines' limited water solubility. There are numerous standard methods for improving the solubility of pharmaceuticals that are poorly soluble, including Media Milling, Homogenization, precipitation technique, et cetera. A new approach in medication development is the development disintegrable medicinal formulations using nanotechnology. Particle sizes used in nanotechnology range are from 1 to 1000 nm. The increase in dissolving rate that results from drug particle size reduction into the submicron region naturally improves bioavailability. An efficient new method for improving the dissolution of low soluble in water medicines is nanosuspension technology. A nanosuspension improves the safety and effectiveness of a medicine by addressing issues with lipophilic like bio-available and poor solvability, as well as by changing the pharmacokinetics.
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