2型糖尿病合并肾功能不全患者血清铁蛋白水平

Prashanthkumar Goudappala, J. Sandhu, Vinay Krishnaiah, S. Palem
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引用次数: 0

摘要

背景与目的:肾病是2型糖尿病(T2DM)终末期肾病(ESRD)的主要原因。2型糖尿病肾病的识别和管理的延迟可能导致ESRD的发展。血清铁蛋白水平升高在T2DM患者慢性肾脏疾病(CKD)的发病机制中起作用。因此,本研究旨在评估2型糖尿病患者肾功能不全时血清铁蛋白水平。材料和方法:这是一项回顾性研究,纳入了81例伴有和不伴有肾病的T2DM患者。他们被分为两组。1组为无肾病的T2DM患者46例,有肾病的35例。采用标准方法测定血糖、尿素、肌酐、铁、铁蛋白、转铁蛋白、总铁结合能力(TIBC)、血红蛋白等临床生化指标,采用MDRD公式估算肾小球滤过率(eGFR)。结果:T2DM合并肾病患者血清铁蛋白、尿素、肌酐水平明显升高(p<0.05)。血清铁蛋白与肌酐呈显著正相关(r = 0.37), eGFR与肌酐呈显著负相关(r = - 0.852)。提示铁蛋白可作为监测T2DM患者肾功能的良好指标。结论:血清铁蛋白水平升高除eGFR和血清肌酐外,也是T2DM患者肾功能不全的良好指标,可能在早期糖尿病肾病肾功能不全中起重要作用。中华医学会医学杂志2022;16(2): 008。DOI: https://doi.org/10.55010/imcjms.16.018*Correspondence: Siva Prasad Palem博士。,医学硕士,博士,医学学院生物化学系,Chalmeda Anand Rao医学科学研究所,印度泰伦加纳邦Karimnagar-505001隶属于Kaloji Narayana Rao健康科学大学(KNRUHS),印度特伦加纳邦瓦朗加尔。电子邮件:sp.biocom@yahoo.co.in。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum ferritin level in type 2 diabetic patients with renal dysfunction
Background and objective: Nephropathy is the major cause of end-stage renal disease (ESRD) in type 2 diabetes mellitus (T2DM). Delay in identification and management of nephropathy in T2DM may cause development of ESRD. An increased level of serum ferritin plays a role in the pathogenesis of chronic kidney disease (CKD) in T2DM. Hence, the present study intended to assess the level of serum ferritin in renal dysfunction in patients with T2DM. Material and methods: This was a retrospective study with 81 T2DM patients with and without nephropathy. They were categorized into two groups. Group-1 consisted of 46 T2DM cases without nephropathy and remaining 35 with nephropathy.The clinical and biochemical parameters such as blood glucose, urea, creatinine, iron, ferritin, transferrin, total iron binding capacity (TIBC), and haemoglobin were measured by standard methods, and estimated glomerular filtration rate (eGFR) by MDRD formula. Results: Significantly (p<0.05) elevated level of serum ferritin along with urea and creatinine was found in patients with T2DM with nephropathy.A significant positive correlation (r = 0.37) of serum ferritin and negative correlation (r = - 0.852) of eGFR with creatinine were found. It indicated that ferritin could be a good marker to monitor kidney function in T2DM. Conclusion: Apart from eGFR and serum creatinine, raised serum ferritin level was a good indicator of renal dysfunction in T2DM patients and might play an important role in renal dysfunction in early stage diabetic nephropathy. IMC J Med Sci 2022; 16(2): 008. DOI: https://doi.org/10.55010/imcjms.16.018 *Correspondence: Dr. Siva Prasad Palem., M.Sc., Ph.D., Department of Biochemistry, Faculty of Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar-505001, Telangana, India. Affiliated with Kaloji Narayana Rao University of Health Sciences (KNRUHS), Warangal, Telangana, India. E-mail: sp.biocom@yahoo.co.in.
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