在普杜切里,在接受疫苗接种的新生儿中,蔗糖和便利的止痛药

S. S, R. Samson, C. Amalraj, S. Sundaresan
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引用次数: 1

摘要

忽视新生儿疼痛会导致各种不良反应,可以通过使用简单、安全的非药物镇痛措施来预防。由于侵入性手术引起的新生儿急性疼痛不推荐使用药物治疗,然而,24%口服蔗糖溶液被发现是有效的。本研究的目的是评估24%口服蔗糖联合便利收纳在通过皮内途径接种卡介苗期间的效果,这在其他地方没有做过。55名符合纳入标准的健康足月新生儿,如胎龄大于37周,出生年龄在24小时内,以及仅通过阴道自然分娩的新生儿被纳入研究。研究干预包括:接种卡介苗前2分钟经皮内途径口服24%蔗糖2ml,接种时方便收纳。在0、3、5分钟累积NIPS评分的主要结果在两个研究组中都不显著。而蔗糖组新生儿的疼痛程度和平均哭泣时间有显著降低。口服24%蔗糖和便利收纳的新生儿与对照组相比,皮内注射后的心率和氧饱和度也有显著差异(p < 0.001)。因此,注射前2分钟口服(24%)蔗糖溶液可有效降低皮内接种后新生儿的疼痛水平。它是一种简单、安全、快速的镇痛药,应考虑用于持续5-7分钟的足月新生儿微创手术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sucrose and Facilitated Tucking for Pain Among Neonates Receiving Vaccination, in Puducherry
Neglected pain in neonates leads to various ill effects and it can be prevented by using simple and safe non-pharmacological pain relieving measures. Pharmacologic agents are not recommended in neonates for acute pain due toinvasive procedures however, administration of 24% oralsucrose solutionis found to be effective. The objective of this study was to assess the efficacy of 24%oral sucrose in combination with Facilitated tucking during BCG Vaccination through intradermalroute in term neonates which is not done elsewhere. Fifty five healthy term neonates who fulfilled the inclusion criteria such as gestational age above 37 weeks, within 24 hoursof birth age, and neonates delivered only through spontaneous vaginal delivery were included in the study. The study intervention consists of administration of 2 ml of oral 24% sucrose 2 minutes before BCG Vaccination through intradermal route and Facilitated tuckingat the time of vaccination. The primary outcome measure of cumulative NIPS score at 0, 3,5 minuteswas not significant in both the study groups. Whereas there was significant reduction in the level of pain and mean cry time in the neonates of sucrose group. Heart rateand oxygen saturation after intradermal injection also showed significant (p less than 0.001) differenceamong the neonates, who received 24% of oral sucroseand Facilitated tucking than for neonates of control group. Thus oral (24%)sucrose solution given 2 minutes before injection was effective in reducing level of neonatal pain following Intradermal Vaccination. It is a simple, safe and fast acting analgesic and should be considered for minor invasive procedures in term neonates which last for 5-7minutes.
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