溴隐亭对地塞米松致高血糖大鼠降糖作用的研究

Rekha M. B., Basavaraj Bhandare, S. V, Hemamalini M. B.
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引用次数: 0

摘要

背景:糖尿病是由胰岛素缺乏或胰岛素抵抗引起的慢性代谢紊乱。最近的动物和人类研究报道溴隐亭对2型糖尿病的治疗有效。研究溴隐亭对地塞米松致高血糖大鼠的降糖作用。方法:选用雄性wistar大鼠,随机分为5组。B-E组采用地塞米松诱导高血糖。A组为未治疗对照组,B组为标准对照组,C组为0.9%生理盐水中溶解溴隐亭10 mg/kg口服,D组为0.9%生理盐水中溶解二甲双胍20 mg/kg口服,E组为10 mg/kg溴隐亭+ 0.9%生理盐水中溶解二甲双胍20 mg/kg口服。测定第1、15、30天的空腹血糖、餐后血糖和体重。结果:地塞米松引起雄性wistar大鼠高血糖和体重增加,口服溴隐亭和溴隐亭联合二甲双胍可明显控制高血糖和体重增加。结论:溴隐亭具有治疗2型糖尿病的新机制,是一种很有前景的药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study on antihyperglycemic effect of bromocriptine in dexamethasone induced hyperglycemic wistar rats
Background: Diabetes mellitus is a chronic metabolic disorder that develops due to insulin deficiency or insulin resistance. Recent animal and human studies have reported bromocriptine to be effective in the management of type 2 diabetes mellitus. The present study was done to evaluate the antihyperglycemic effect of bromocriptine in dexamethasone induced hyperglycemic rats. Methods: Male wistar rats were used and divided into 5 groups. Dexamethosone was used to induce hyperglycemia in group B-E. Group A was the untreated control group, group B was the standard control group, group C was the oral 10 mg/kg of bromocriptine dissolved in 0.9% normal saline, group D was the oral 20 mg/kg metformin dissolved in 0.9% normal saline, group E was the oral 10 mg/kg bromocriptine+20 mg/kg metformin dissolved in 0.9% normal saline. Fasting blood glucose, post prandial blood glucose and body weight was estimated on day 1, 15, 30. Results: It was seen that dexamethasone induced hyperglycemia and increase in body weight in male wistar rats, which were significantly controlled by oral bromocriptine and bromocriptine with metformin combination. Conclusions: Results obtained from this study showed that bromocriptine can be a promising drug with novel mechanism to treat type 2 diabetes mellitus.
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