阳离子卟啉-咪唑吩偶联物的合成、结构及抗增殖活性研究

International Review of Biophysical Chemistry Pub Date : 2011-08-30 DOI:10.15866/IREBIC.V2I4.1527

L. Dubey, Mykola M. Ilchenko, V. Zozulya, O. Ryazanova, P. Pogrebnoy, I. Dubey

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引用次数: 5

摘要

合成了g -四络合物阳离子三(甲基吡啶)卟啉及其与中性插层剂咪唑非那嗪的锌(II)和锰(III)金属配合物。卟啉的羧基烷基衍生物与n -氨基烷基化染料偶联合成。光谱荧光研究和密度泛函量子化学计算表明，非金属化杂化和锌(II)衍生物的两个发色团之间形成了分子内配合物。该偶联物在体外微摩尔浓度下抑制小鼠Lewis肺癌肿瘤细胞的生长。金属配合物的活性是非金属杂化物的几倍。最有效的Zn(II)复合物抑制肿瘤细胞的IC50为5.9M

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Synthesis, Structure and Antiproliferative Activity of Cationic Porphyrin - Imidazophenazine Conjugate

New conjugate of G-quadruplex ligand, cationic tris(methylpyridinium)porphyrin, and its Zn(II) and Mn(III) metal complexes with a neutral intercalating agent imidazophenazine were synthesized. The synthesis was based on the coupling of carboxyalkyl derivative of the porphyrin with N1-aminoalkylated dye. Spectral-fluorescent studies and density functional quantum-chemical calculations suggest the formation of intramolecular complexes between the two chromophores for non-metalated hybrid and zinc(II) derivative. The conjugates have been found to inhibit the growth of tumor cells of mouse Lewis lung carcinoma in vitro at micromolar concentrations. Metal complexes were several times more active than the non-metalated hybrid. The most efficient Zn(II) complex suppressed the tumor cells with IC50 5.9 M

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International Review of Biophysical Chemistry

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