格陵兰岛努克地区因纽特妇女跟骨超声检测骨强度的决定因素

A. Paunescu, P. Ayotte, S. Dodin, É. Dewailly, G. Mulvad, H. Pedersen, S. Côté
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引用次数: 1

摘要

本研究是通过定量超声(QUS)在格陵兰因纽特妇女的跟骨估计确定骨强度的决定因素。共有153名来自努克的因纽特妇女,年龄从49岁到64岁,参加了第一次QUS测量(2000年),使用阿基里斯月球仪器(声速(SOS));宽带超声衰减(BUA);刚度指数(SI))。两年后(2002年)对121名参与者进行了第二次测量。其中118人在基线时记录了与骨强度相关的几个已知因素。在线性回归中使用自动(逐步)选择变量来确定QUS参数的决定因素。基线QUS测量的重要决定因素是所有QUS参数的年龄和体重,BUA和SI的身高,以及SI的激素替代疗法(HRT)使用。随访QUS测量的重要预测因子是基线QUS值、吸烟状况和所有QUS参数的HRT使用情况、红细胞膜磷脂(BUA和SI)的omega-3/omega-6 PUFA含量比和绝经状态(BUA)。一些可改变的饮食因素,如富含omega-3 PUFAs的饮食和生活方式因素(如吸烟、服用激素替代疗法),在两年的随访后被证明决定了QUS参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Determinants of Bone Strength Estimated by Calcaneal Ultrasonography in Inuit Women from Nuuk (Greenland)
This study was conducted to identify determinants of bone strength estimated by quantitative ultrasonography (QUS) at the calcaneus of Greenlandic Inuit women. A total of 153 Inuit women from Nuuk, aged from 49 to 64 years, participated in the first QUS measurement (year 2000) with an Achilles Lunar instrument (speed of sound (SOS); broadband ultrasound attenuation (BUA); stiffness index (SI)). A second measurement was performed two years later (year 2002) in 121 participants. Several factors known to be associated with bone strength were recorded at baseline for 118 of them. Determinants of QUS parameters were identified using an automatic (stepwise) selection of variables in linear regression. Significant determinants of baseline QUS measurements were age and body weight for all QUS parameters, height for BUA and SI, and hormone replacement therapy (HRT) use for SI. Significant predictors of follow-up QUS measurements were baseline QUS values, the smoking status and HRT use for all QUS parameters, omega-3/omega-6 PUFA content ratio of erythrocytes membrane phospholipids (BUA and SI), and menopausal status (BUA). Several modifiable dietary factors, such as a diet rich in omega-3 PUFAs and lifestyle factors (i.e., smoking, taking HRT), were shown to determine QUS parameters after a follow-up of two years.
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