抗癌无机环-DNA相互作用的拉曼研究

Michel Manfait, Jean-François Labarre
{"title":"抗癌无机环-DNA相互作用的拉曼研究","authors":"Michel Manfait,&nbsp;Jean-François Labarre","doi":"10.1016/0378-4487(81)80024-6","DOIUrl":null,"url":null,"abstract":"<div><p>A Raman investigation of pentaziridinocyclodiphosphathiazene -DNA interactions in vitro suggests that the alkylating sites on DNA for this powerful antitumour agent are essentially the oxygen atoms of the ribose backbone with a second order dialkylating effect on the N(7) and <span><math><mtext>N</mtext></math></span>H<sub>2</sub> positions of Adenine. These contrasts with the case of hexaziridinocyclotriphosphazene which interacts with the DNA by the same two routes but through a balanced mode.</p></div>","PeriodicalId":100049,"journal":{"name":"Advances in Molecular Relaxation and Interaction Processes","volume":"21 2","pages":"Pages 117-130"},"PeriodicalIF":0.0000,"publicationDate":"1981-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0378-4487(81)80024-6","citationCount":"8","resultStr":"{\"title\":\"Raman studies on anticancer inorganic ring -DNA interactions\",\"authors\":\"Michel Manfait,&nbsp;Jean-François Labarre\",\"doi\":\"10.1016/0378-4487(81)80024-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A Raman investigation of pentaziridinocyclodiphosphathiazene -DNA interactions in vitro suggests that the alkylating sites on DNA for this powerful antitumour agent are essentially the oxygen atoms of the ribose backbone with a second order dialkylating effect on the N(7) and <span><math><mtext>N</mtext></math></span>H<sub>2</sub> positions of Adenine. These contrasts with the case of hexaziridinocyclotriphosphazene which interacts with the DNA by the same two routes but through a balanced mode.</p></div>\",\"PeriodicalId\":100049,\"journal\":{\"name\":\"Advances in Molecular Relaxation and Interaction Processes\",\"volume\":\"21 2\",\"pages\":\"Pages 117-130\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0378-4487(81)80024-6\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Molecular Relaxation and Interaction Processes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0378448781800246\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Molecular Relaxation and Interaction Processes","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0378448781800246","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8

摘要

在体外对五氮基二环二磷噻嗪-DNA相互作用的拉曼研究表明,这种强大的抗肿瘤药物在DNA上的烷基化位点本质上是核糖骨架上的氧原子,对腺嘌呤的N(7)和NH2位置具有二级二烷基化作用。这与六氮基二环三磷腈的情况形成对比,六氮基二环三磷腈通过相同的两条途径与DNA相互作用,但通过平衡模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Raman studies on anticancer inorganic ring -DNA interactions

A Raman investigation of pentaziridinocyclodiphosphathiazene -DNA interactions in vitro suggests that the alkylating sites on DNA for this powerful antitumour agent are essentially the oxygen atoms of the ribose backbone with a second order dialkylating effect on the N(7) and NH2 positions of Adenine. These contrasts with the case of hexaziridinocyclotriphosphazene which interacts with the DNA by the same two routes but through a balanced mode.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信