{"title":"淫羊藿苷通过调控STAT3激活抑制人鼻咽癌细胞CNE2增殖、迁移和侵袭的作用","authors":"Xiangdong Li, Chunlei Li, Peiyu Zhou, Shaohua Chen","doi":"10.1691/ph.2019.9632","DOIUrl":null,"url":null,"abstract":"The influence of icaritin on the proliferation, migration, and invasion of human nasopharyngeal carcinoma cell CNE2 and the influencing mechanisms were discussed. Results indicated that icaritin can realize dosage-dependent inhibition of CNE2 cell proliferation, migration, and invasion and inhibit the expression levels of VEGF, KDR, bFGF, MMP2, and MMP9. It can also inhibit STAT3 phosphorylation without affecting STAT3 expression. Icaritin exerts multiple bonding effects on the SH2 structural domain of STAT3. Therefore, icaritin can become a candidate drug for resisting nasopharyngeal carcinoma, and its mechanism is related to the blocking of STAT3 signaling pathway activation.","PeriodicalId":86039,"journal":{"name":"Die Pharmazie. Beihefte","volume":"42 1","pages":"685-687"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Inhibitory effect of icaritin on proliferation, migration, and invasion of human nasopharyngeal carcinoma cell CNE2 by regulating STAT3 activation.\",\"authors\":\"Xiangdong Li, Chunlei Li, Peiyu Zhou, Shaohua Chen\",\"doi\":\"10.1691/ph.2019.9632\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The influence of icaritin on the proliferation, migration, and invasion of human nasopharyngeal carcinoma cell CNE2 and the influencing mechanisms were discussed. Results indicated that icaritin can realize dosage-dependent inhibition of CNE2 cell proliferation, migration, and invasion and inhibit the expression levels of VEGF, KDR, bFGF, MMP2, and MMP9. It can also inhibit STAT3 phosphorylation without affecting STAT3 expression. Icaritin exerts multiple bonding effects on the SH2 structural domain of STAT3. Therefore, icaritin can become a candidate drug for resisting nasopharyngeal carcinoma, and its mechanism is related to the blocking of STAT3 signaling pathway activation.\",\"PeriodicalId\":86039,\"journal\":{\"name\":\"Die Pharmazie. Beihefte\",\"volume\":\"42 1\",\"pages\":\"685-687\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Die Pharmazie. Beihefte\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1691/ph.2019.9632\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Die Pharmazie. Beihefte","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1691/ph.2019.9632","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Inhibitory effect of icaritin on proliferation, migration, and invasion of human nasopharyngeal carcinoma cell CNE2 by regulating STAT3 activation.
The influence of icaritin on the proliferation, migration, and invasion of human nasopharyngeal carcinoma cell CNE2 and the influencing mechanisms were discussed. Results indicated that icaritin can realize dosage-dependent inhibition of CNE2 cell proliferation, migration, and invasion and inhibit the expression levels of VEGF, KDR, bFGF, MMP2, and MMP9. It can also inhibit STAT3 phosphorylation without affecting STAT3 expression. Icaritin exerts multiple bonding effects on the SH2 structural domain of STAT3. Therefore, icaritin can become a candidate drug for resisting nasopharyngeal carcinoma, and its mechanism is related to the blocking of STAT3 signaling pathway activation.
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