45-69岁成人非高密度脂蛋白高胆固醇与代谢综合征、糖尿病和动脉高血压的关系

Q4 Medicine
G. Simonova, S. Mustafina, O. Rymar, C. K. Malyutina, L. Sherbakova, A. P. Kashirina, Y. Nikitin, Y. Ragino
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AH was diagnosed at systolic BP levels ≥ 140 mm hg. art. or diastolic BP ≥ 90 mm hg. art. and/or taking antihypertensive drugs within the last 2 weeks. Persons with previously diagnosed AH, but with normotonia at screening in cases of taking drugs that reduce BP, were also counted as patients with AH. DM2 was diagnozed — according to WHO criteria, 1999, ADA, 2013 — at fasted plasma glucose level ≥ 7,0 mmol/l and persons with previously diagnosed DM2. MS and its components were diagnosed according to IDF criteria (2005).Results. The mean value of non-HDL cholesterol in the general population of Novosibirsk aged 45–69 were 4,7 ± 1,3 mmol/l and were higher in women than in men — 4,9 ± 1,3 mmol/l and 4,5 ± 1,2 mmol/l, (p < 0,0001). The prevalence of hypercholesterol-non-HDL in women varies from 84,7 to 94,3% — and is significantly higher than in men — 80,6 to 84,1%. 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引用次数: 0

摘要

目标。研究西伯利亚地区45 ~ 69岁人群非高密度脂蛋白高胆固醇(non-HDL-C)患病率及代谢综合征(MS)、2型糖尿病(DM2)、动脉高血压(AH)等心血管代谢危险因素的非高密度脂蛋白高胆固醇(non-HDL-C)平均水平。设计和方法。评价AН、MS、T2D人群的动脉粥样硬化性血脂异常的依据是2003-2005年HAPIEE随机抽样n = 9360人的HAPIEE项目西伯利亚分支资料。研究计划包括问卷调查、血压测量、人体测量、生化筛查。值≥3,4 mmol/l被认为是高胆固醇-非hdl。在收缩压≥140 mm hg. art时诊断AH。或舒张压≥90mmhg。和/或在过去两周内服用抗高血压药物。先前诊断为AH的人,但在服用降压药物的情况下,在筛查时表现为血压正常,也算作AH患者。根据WHO 1999年、ADA 2013年的标准,空腹血糖水平≥7.0 mmol/l且既往诊断为DM2的患者被诊断为DM2。根据IDF诊断标准(2005)诊断多发性硬化症及其组成部分。新西伯利亚45 ~ 69岁人群非高密度脂蛋白胆固醇均值为4.7±1.3 mmol/l,女性高于男性(4.9±1.3 mmol/l和4.5±1.2 mmol/l,差异有统计学意义(p < 0.0001)。高胆固醇非高密度脂蛋白在女性中的患病率从84.7%到94.3%不等,明显高于男性(84.6%到84.1%)。非高密度脂蛋白胆固醇水平≥3,4 mmol/l的被检查者占86.8%,11%(在2,6 - 3,39范围内)低于2,6 mmol/l,只有2.2%(低于2,6 mmol/l)。在三个队列(DM2、MS和AH组)中,男性和女性的非hdl - c平均值在DM2组最高,MS组低于DM组,AH组低于MS和DM2组。在DM2队列中,根据非hdl - c≥3,4 mmol/l的标准,有89.4%的男性和95.7%的女性检测出非hdl - c;在患有多发性硬化症的人群中,在45-69岁的西伯利亚人群中,有92.4%的男性和95.5%的女性发现了多发性硬化症,有85.5%的男性和92.5%的女性发现了多发性硬化症。AH、MS和DM2在非hdl - c分布的第5个五分位数中的频率高于第1个五分位数(p < 0.0001),且这些指标在女性人群中占优势。据研究,非hdl - c的含量及其在人群中的患病率较高,特别是在DM2、MS、AH患者中。在建立预防心血管疾病、MS和DM2的平台方面,非hdl - c比值值得关注,作为进一步研究的目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of non-high-density lipoprotein hypercholesterol with metabolic syndrome, diabetes and arterial hypertension in the population of 45–69 years adults
Objective. To study the prevalence of non-high-density lipoprotein hypercholesterol (non-HDL–C) and the average levels of non-HDL–C in metabolic syndrome (MS), type 2 diabetes mellitus (DM2), arterial hypertension (AH) and other cardiometabolic risk factors in the Siberian population aged 45–69 years.Design and methods. The evaluation of atherogenic dyslipidemia among persons with AН, MS, T2D was based on the materials of Siberian branch of HAPIEE project in the random sample n = 9360 surveyed in 2003–2005 HAPIEE. The study program included questionnaire survey, blood pressure (BP) measurement, anthropometry, biochemical screening. The value ≥ 3,4 mmol/l was considered as hypercholesterol-non-HDL. AH was diagnosed at systolic BP levels ≥ 140 mm hg. art. or diastolic BP ≥ 90 mm hg. art. and/or taking antihypertensive drugs within the last 2 weeks. Persons with previously diagnosed AH, but with normotonia at screening in cases of taking drugs that reduce BP, were also counted as patients with AH. DM2 was diagnozed — according to WHO criteria, 1999, ADA, 2013 — at fasted plasma glucose level ≥ 7,0 mmol/l and persons with previously diagnosed DM2. MS and its components were diagnosed according to IDF criteria (2005).Results. The mean value of non-HDL cholesterol in the general population of Novosibirsk aged 45–69 were 4,7 ± 1,3 mmol/l and were higher in women than in men — 4,9 ± 1,3 mmol/l and 4,5 ± 1,2 mmol/l, (p < 0,0001). The prevalence of hypercholesterol-non-HDL in women varies from 84,7 to 94,3% — and is significantly higher than in men — 80,6 to 84,1%. The level of non-HDL cholesterol ≥ 3,4 mmol/l was observed in 86,8% of the examined, 11% — in the range of 2,6–3,39 and only 2,2% — less than 2,6 mmol/l. The average values of non-HDL–C in men and women in three cohorts (with DM2, MS and AH) were found to be the highest in DM2, lower in MS than in DM, and lower in AH than in MS and DM2. In the cohort with DM2, non-HDL–C, according to the criterion of non-HDL–C ≥ 3,4 mmol/l, was determined in 89,4% of men and 95,7% of women; in persons with MS, it was found in 92,4% of men and 95,1% of women, with AH — in 85,2% of men and 92,5% of women of the Siberian population aged 45–69 years. The frequencies of AH, MS and DM2 in the 5th quintile of the distribution of non-HDL–C are higher compared to the first quintile (p < 0,0001), with a predominance of these indicators in the female population.Conclusions. According to study, the content of non-HDL–C, and its prevalence of elevated levels in the population is high, especially in people with DM2, MS, AH. In terms of developing a platform for prevention of cardiovascular diseases, MS and DM2, the non-HDL–C ratio deserves attention as a target for further research.
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来源期刊
Arterial Hypertension (Russian Federation)
Arterial Hypertension (Russian Federation) Medicine-Cardiology and Cardiovascular Medicine
CiteScore
0.90
自引率
0.00%
发文量
38
期刊介绍: The main aims of the Journal include collecting and generalizing the knowledge in hypertensiology; education and professional development of cardiologists and medical doctors of other specialties, who deal with different issues regarding diagnostics, management and prevention of hypertension in both clinical practice and research. The Journal also calls attention to the most urgent and up-to-date questions in hypertensiology, cardiology and related sciences. There are additional objectives, such as increasing the availability, accessibility and recognition of Russian medical scientific achievements at the international level by improving the quality of the publication and the way they are presented; enabling the exchange of opinions and information between scientists and their wider communication. The main criteria for publication selection fit with the mentioned objectives and include currency, singularity, scientific and practical novelty, applied relevance etc.
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