Post-injection necrosis of femoral soft tissues induced by diclofenac, nonsteroidal anti-inflammatory drug (clinical case)

Nikolau syndrome is a rare post-injection complication with unclear etiology and pathogenesis, characterized by the development of acute local pain syndrome, localized erythematous rash, livedoid and hemorrhagic skin lesions with foci of ischemic necrosis. The paper presents a clinical case of Nikolau syndrome induced by intramuscular administration of diclofenac solution as an analgesic after hip replacement. The analysis of the causes, clinical picture and stages of treatment of post-injection complication was carried out.