{"title":"甲基钴胺素在水溶液和甲醇溶液中自发转化为羟钴胺素的动力学","authors":"Stanislav V. Yefimov","doi":"10.36347/sajp.2022.v11i10.001","DOIUrl":null,"url":null,"abstract":"This work aimed to determine the stability of methylcobalamin in injection solutions under light-protected conditions, identify the products of its spontaneous transformation, and determine the kinetics of these transformations. We have found that methylcobalamin is unstable and transforms into hydroxocobalamin spontaneously at room temperature in aqueous and methanol solutions protected from light. Kinetics, reaction products, and rate constants have been determined. A method for the qualitative and quantitative determination of methylcobalamin and its conversion products is proposed.","PeriodicalId":21439,"journal":{"name":"Scholars Academic Journal of Pharmacy","volume":"328 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Kinetics of Spontaneous Conversion of Methylcobalamin into Hydroxocobalamin in Aqueous and Methanol Solutions HPLC/MS\",\"authors\":\"Stanislav V. Yefimov\",\"doi\":\"10.36347/sajp.2022.v11i10.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This work aimed to determine the stability of methylcobalamin in injection solutions under light-protected conditions, identify the products of its spontaneous transformation, and determine the kinetics of these transformations. We have found that methylcobalamin is unstable and transforms into hydroxocobalamin spontaneously at room temperature in aqueous and methanol solutions protected from light. Kinetics, reaction products, and rate constants have been determined. A method for the qualitative and quantitative determination of methylcobalamin and its conversion products is proposed.\",\"PeriodicalId\":21439,\"journal\":{\"name\":\"Scholars Academic Journal of Pharmacy\",\"volume\":\"328 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-11-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scholars Academic Journal of Pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36347/sajp.2022.v11i10.001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scholars Academic Journal of Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36347/sajp.2022.v11i10.001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Kinetics of Spontaneous Conversion of Methylcobalamin into Hydroxocobalamin in Aqueous and Methanol Solutions HPLC/MS
This work aimed to determine the stability of methylcobalamin in injection solutions under light-protected conditions, identify the products of its spontaneous transformation, and determine the kinetics of these transformations. We have found that methylcobalamin is unstable and transforms into hydroxocobalamin spontaneously at room temperature in aqueous and methanol solutions protected from light. Kinetics, reaction products, and rate constants have been determined. A method for the qualitative and quantitative determination of methylcobalamin and its conversion products is proposed.
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