褪黑素、心血管疾病和COVID-19:一种潜在的治疗策略?

Melatonin Research Pub Date : 2020-06-15 DOI:10.32794/mr11250065

A. Domínguez-Rodríguez, P. Abreu-González, P. Marik, R. Reiter

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引用次数: 9

摘要

SARS-CoV-2感染的机制是病毒必须与膜结合形式的血管紧张素转换酶2 (ACE2)结合，并由宿主细胞内化该复合物。SARS-CoV-2诱导的内皮功能障碍和心血管损伤可能是由JAK2和STAT3磷酸化水平升高以及由此产生的活性氧(ROS)形成引发的。据推测，褪黑素显著地逆转了这些病理改变

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Melatonin, cardiovascular disease and COVID-19: A potential therapeutic strategy?

The mechanism for SARS-CoV-2 infection is the requisite binding of the virus to the membrane-bound form of angiotensin-converting enzyme 2 (ACE2) and internalization of the complex by the host cell. SARS-CoV-2 induced endothelial dysfunction and cardiovascular injury are probably initiated by increases in the phosphorylation levels of JAK2 and STAT3 and resultant reactive oxygen species (ROS) formation. These pathological alterations are speculated to be strikingly reversed by melatonin

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Melatonin Research

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