Wound healing in compound fractures with significant tissue loss: Treated with platelet-rich fibrin dressing - prospective study

Introduction: Platelet-rich fibrin (PRF) naturally derived second generation of platelet concentrates, which has gained increasing awareness in recent years for regenerative procedures. This biologic additive is completely autologous, easy to prepare, has minimal expense, and possesses prolonged growth factor release, together with several other advantages over traditionally prepared platelet concentrates. However, reference data about potential effect of some PRF components on hard and soft tissue healing are still conflicting. The current article intends to clarify the relevant advances about physiological role of certain PRF components on wound healing in 50 patients. In this study shows effective wound healing in limited duration with p value of < 0.005. Conclusion: PRF has more regenerative progression than other platelet concentrators easily available, affordable and inexpensive for wound healing in minimal duration.