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引用次数: 0
摘要
摘要:5′-同马马霉素的C-5′非对映体的制备分6步进行，首先采用手性Evans n -酰基氧唑烷酮在Michael反应中制备了易于获得的(3aR,6aR)-2,2-二甲基- 2h,3aH,4H, 6ah -环五[1,3]二恶醇-4- 1，用于指导所需侧链立体化学。对这两种靶标进行了针对一系列病毒的评估，发现它们仅对黄热病具有活性。两种化合物均无细胞毒性。
The Synthesis of Both Diastereomers of 5′-Methylhomoaristeromycin
GRAPHICAL ABSTRACT ABSTRACT The preparation of the C-5′ diastereomers of 5′-homoaristeromycin has been achieved in 6 steps beginning with readily available (3aR,6aR)-2,2-dimethyl-2H,3aH,4H,6aH-cyclopenta[1,3]dioxol-4-one in a Michael reaction employing chiral Evans N-acyloxazolidinones that served to direct the requisite side chain stereochemistry. The two targets were evaluated against a battery of viruses and found to possess activity only towards yellow fever. Both compounds were non-cytotoxic.
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