使用VSRAD Advance评价阿尔茨海默病和痴呆与路易体评分的相关性

Y. Okada, N. Ohno, Koji Kariya-city Aichi-pref. Tanaka
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引用次数: 0

摘要

本研究的目的是利用基于体素的阿尔茨海默病特异性区域分析系统(VSRAD)的进展,探讨阿尔茨海默病和痴呆指标与路易体的关系。2019年3月1日至10月30日,在36例疑似痴呆患者中,使用VSRAD advance识别阿尔茨海默病和伴路易体痴呆患者。所有患者均行脑磁共振成像(MRI)检查。我们使用内侧颞叶(MTL)萎缩比> 2的感兴趣体积(VOI)诊断阿尔茨海默病,使用MTL萎缩比≤2和灰质/白质萎缩比≥0.2的VOI诊断路易小体痴呆。计算阿尔茨海默病和痴呆指标与路易体的相关性。被归类为阿尔茨海默病和路易体痴呆的患者分别为25名和11名。在阿尔茨海默病组中,脑干背侧灰质萎缩程度与萎缩严重程度的相关系数为r = -0.40 (p = 0.045)。路易体痴呆组脑灰质萎缩程度与脑干背侧白质萎缩程度的相关系数为r = -0.78 (p < 0.01)。应用VSRAD技术,发现脑灰质萎缩和背侧脑干灰质/白质萎缩与阿尔茨海默病和痴呆与路易体呈负相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation between Alzheimer’s Disease and Dementia with Lewy Bodies Scores Using VSRAD Advance
The objective of the study was to explore the relationship between the indicators of Alzheimer’s disease and dementia with Lewy bodies using the voxel-based specific regional analysis system for Alzheimer’s Disease (VSRAD) advance. Among 36 patients with suspected dementia, patients with Alzheimer’s disease and dementia with Lewy bodies were identified using VSRAD advance from March 1 to October 30, 2019. All patients underwent brain Magnetic Resonance Imaging (MRI). We diagnosed Alzheimer’s disease using Volume of Interest (VOI) in the Medial Temporal Lobe (MTL) atrophy ratio > 2 and dementia with Lewy bodies using both VOI in the MTL atrophy ratio ≤ 2 and gray/white matter atrophy ratio ≥ 0.2. The correlation between the indicators of Alzheimer’s disease and dementia with Lewy bodies was calculated. The number of patients classified as having Alzheimer’s disease and dementia with Lewy bodies was 25 and 11, respectively. In the Alzheimer’s disease group, the correlation coefficient between the extent of gray matter atrophy and the severity of atrophy in the dorsal brainstem gray matter was r = -0.40 (p = 0.045). In dementia with Lewy bodies group, the correlation coefficient between the extent of gray matter atrophy and the severity of atrophy in the dorsal brainstem white matter was r = -0.78 (p < 0.01). Using VSRAD advance, gray matter atrophy and dorsal brainstem grey/white matter atrophy were found to be negatively correlated in Alzheimer’s disease and dementia with Lewy bodies.
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