Myelodysplastic syndrome developed after leucosis polychemotherapy. Result of therapy or manifestation of genetic instability?

Great progress has been achieved in the treatment of oncological diseases; however, the problem of the occurrence of secondary malignant neoplasms remains actual, among which hematologic malignancies are common. The development of secondary tumors is of particular interest, because the individual predisposition of the body to malignant transformation of cells and the carcinogenic effect of antitumor therapy of primary cancer are possible etiological factors. The article presents a review of literature devoted to the cases of secondary malignant neoplasms that emerged after antitumor treatment. A clinical case of a secondary myelodysplastic syndrome developed after chemotherapy in the treatment of primary acute lymphoblastic leukemia is described.