含甲基环己烯和二甲基环己烯的内酯结构对其生物转化和抗菌活性的影响

Katarzyna Wińska, M. Grabarczyk, Wanda Mączka, B. Żarowska, G. Maciejewska, M. Anioł
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引用次数: 5

摘要

摘要本文研究了含甲基环己烯和二甲基环己烯的内酯结构对其生物转化和抗菌活性的影响。这项工作是基于一个普遍的观点,即即使是化合物结构上最小的变化也会影响它的生物学特性。利用15株真菌(镰刀菌属、青霉属、Absidia属、Cunninghamella japonica、Pleurotus ostreatus)和5株酵母菌(Yarrowia lipolytica、Rhodorula marina、Rhodorula rubra、Candida viswanathii、Saccharomyces cerevisiae)对4种环己烯环上含有1个或2个甲基的双环不饱和内酯进行了生物转化试验。在这些转化过程中,得到了新的环氧内酯和羟内酯。分析了底物结构与微生物转化底物能力的关系。真菌只转化了内酯环C-O键位于赤道位置的化合物。所有在这里提出的内酯也检查了他们的抗菌活性。结果表明,这些化合物对细菌和真菌的生长具有抑制作用,主要是枯草芽孢杆菌、白色念珠菌、黑曲霉和扩张青霉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of structure of lactones with the methylcyclohexene and dimethylcyclohexene ring on their biotransformation and antimicrobial activity
Abstract The aim of this article is influence of the structure of lactones with the methylcyclohexene and dimethylcyclohexene ring on their biotransformation and antimicrobial activity. This work was based on the general remark that even the smallest change in the structure of a compound can affect its biological properties. The results of the biotransformation of four bicyclic unsaturated lactones with one or two methyl groups in the cyclohexene ring was tested using fifteen fungal strains (Fusarium species, Penicillium species, Absidia species, Cunninghamella japonica, and Pleurotus ostreatus) and five yeast strains (Yarrowia lipolytica, Rhodorula marina, Rhodorula rubra, Candida viswanathii, and Saccharomyces cerevisiae). During these transformations, new epoxylactone and hydroxylactone were obtained. The relationship between the substrate structure and the ability of the microorganisms to transform them were analysed. Only compounds with C–O bond of lactone ring in the equatorial position were transformed by fungus. All presented here lactones were examined also for their antimicrobial activity. It turned out that these compounds exhibited growth inhibition of bacteria and fungi, mainly Bacillus subtilis, Candida albicans, Aspergillus niger, and Penicillium expansum.
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