Hyperforin: A lead for antidepressants

Depression is a complex but treatable disorder if diagnosed appropriately. However, despite the advances in the understanding of the molecular basis of this disorder and the vast range of medication, psychotherapy and electroconvulsive therapy, very safe and effective drug to treat this disease is still being sought. Several studies suggest that St.John’s wort (Hypericum perforatum L.) has phloroglucinol derivative, hyperforin, exhibiting antidepressant activity. This bioactive component can be exploited to create a major shift in the safer treatment of depression. Keywords: Hypericum perforatum L., St. John's wort, Antidepressant, Hyperforin