POTENTIATION OF PROBIOTIC ACTIVITY BY SIMULTANEOUS USE OF AEROCOCCUS VIRIDANS AND MYCOBACTERIUM VACCAE

In modern animal husbandry, progressive intensive technologies for keeping animals and the productive exploitation of animals are economically efficient, but they deplete the physiological reserves of the body and lead to undesirable pathophysiological changes of a complex nature. The immune-reactive potential of the integral and censoring systems of the macroorganism decreases, the metabolic activity of enzyme complexes at the level of cells and organs changes, antimicrobial resistance decreases, and the quantitative and qualitative composition of the normal flora of the covering tissues and hollow organs is disturbed. The stress of debilitating technological leads to systemic pathologies of infectious and non-infectious origin and deterioration of the health and well-being of the animals. One of the physiological ways of correcting the systemic pathology based on damage to the native bioprotective mechanisms of the macroorganism is the use of resident prokaryotes of the microbiome artificially cultivated and given per os as a feed dietary supplement. In our research, we isolated probiotic cultures of A. viridans and M. vaccae from healthy broiler chickens, studied their biological properties, established their biosafety for other animals, and determined probiotic potencies when used monovalently and in association. It was shown that the combined use of probiotic prokaryotes significantly improves the stimulation of the immune-reactive potential of the macroorganism and, in association, increases the colonization capabilities of indigenous prokaryotes. Isolated probiotic cultures of the resident microbiota are suitable for the production of probiotics and symbiotics for farm and domestic animals and for prophylactic and therapeutic use both in monoculture and in association. Simultaneous use of probiotic associations is more effective than monocultures.