眼相干断层扫描对糖尿病视网膜病变与非糖尿病视网膜病变患者视网膜神经纤维层厚度的比较

Isha Aslam, Sadaf Qayyum, Maryam Firdous, S. Ullah
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摘要

目的:利用眼相干体层摄影技术,研究糖尿病患者、糖尿病视网膜病变患者和健康人的视网膜厚度。方法:来自三级眼科医院门诊和视网膜科的101例患者参与了本研究。采用横断面研究设计。采用非概率连续抽样作为采样技术。根据纳入标准选择患者。使用ETDRS早期治疗糖尿病视网膜病变研究视力表在距离6米处评估视力。医生完成眼科检查后,行眼相干断层扫描(Heidelberg Spectralis)评估RNFL厚度。不同类型的糖尿病视网膜病变、2型糖尿病、正常健康和视网膜RNFL厚度之间的关系使用单因素方差分析检验确定。结果:年龄40 ~ 69岁,平均55.68±10.437岁。15.3%的人患有糖尿病1至5年。24%的人患有糖尿病6至10年,19.9%的人患有糖尿病,病程19.9%。与正常健康人相比,2型糖尿病患者、NPDR和PDR患者的RNFL厚度显著降低(p< 0.001)。糖尿病患者年龄、病程与视网膜神经纤维层数密切相关(p<0.001)。结论:本研究表明,糖尿病视网膜病变(NPDR、PDR)、2型糖尿病患者和健康人的视网膜神经纤维层(RNFL)在各象限均明显变薄。年龄、糖尿病病程与RNFL平均厚度显著相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Retinal Nerve Fiber Layer Thickness in Diabetic Patients with and without Diabetic Retinopathy and Healthy Individuals using Ocular Coherence Tomography
Objectives: Using Ocular Coherence Tomography, the study aimed to examine the RNFL thickness of type diabetics, patients with Diabetic Retinopathy, and healthy persons. Methods: 101 patients from the outside patient department and the Retina department of Tertiary Eye Care Hospital participated in this research. The cross-sectional study design was used. Non-probability consecutive sampling was utilized as the sampling technique. Patients were selected according to inclusion criteria. Visual Acuity was assessed using an (ETDRS) Early Treatment Diabetic Retinopathy Study Visual acuity chart at a distance of 6m. After the Ophthalmological Examination was done by a doctor, Ocular Coherence Tomography (Heidelberg Spectralis) was performed to assess RNFL thickness. The association between different types of diabetic retinopathy, Type-2 Diabetes, Normal Healthy, and retinal RNFL thickness was determined using a one-way ANOVA test. Results: The age range of the participants was between 40 and 69 years, with a mean of 55.68 ±10.437 years. 15.3% had diabetes for 1 to 5 years. 24% had Diabetes for 6 to 10 yea 19.9% had a Diabetes duration of 19.9%. The RNFL thickness was significantly decreased in type 2 diabetics, NPDR, and PDR as compared to normal Healthy individuals (p<.001). Age and duration of diabetes were closely correlated with the retinal nerve fiber layer (p<0.001). Conclusion: This study indicated that the (retinal nerve fiber layer) RNFL was considerably thinner in all quadrants of diabetic retinopathy (NPDR, PDR), type 2 diabetics, and healthy persons. Age and duration of diabetes were significantly correlated with average RNFL thickness.
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