A. Ermolaeva, G.K. Vladimirov, S. Gordleeva, A. Zaikin, P. S. Timashev
{"title":"体外研究的数字化建模","authors":"A. Ermolaeva, G.K. Vladimirov, S. Gordleeva, A. Zaikin, P. S. Timashev","doi":"10.37747/2312-640x-2021-19-134-136","DOIUrl":null,"url":null,"abstract":"In this work, an integrated mathematical model of the liver cell, cholesterol metabolism, and drug interactions was developed. The model reproduced the well-known biology of cholesterol regulation, which confirms its potential for minimizing cellular research in the initial testing of new drugs for cardiology.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"224 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"DIGITAL MODELING OF IN VITRO RESEARCH\",\"authors\":\"A. Ermolaeva, G.K. Vladimirov, S. Gordleeva, A. Zaikin, P. S. Timashev\",\"doi\":\"10.37747/2312-640x-2021-19-134-136\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this work, an integrated mathematical model of the liver cell, cholesterol metabolism, and drug interactions was developed. The model reproduced the well-known biology of cholesterol regulation, which confirms its potential for minimizing cellular research in the initial testing of new drugs for cardiology.\",\"PeriodicalId\":13077,\"journal\":{\"name\":\"http://eng.biomos.ru/conference/articles.htm\",\"volume\":\"224 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"http://eng.biomos.ru/conference/articles.htm\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37747/2312-640x-2021-19-134-136\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"http://eng.biomos.ru/conference/articles.htm","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37747/2312-640x-2021-19-134-136","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In this work, an integrated mathematical model of the liver cell, cholesterol metabolism, and drug interactions was developed. The model reproduced the well-known biology of cholesterol regulation, which confirms its potential for minimizing cellular research in the initial testing of new drugs for cardiology.
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