中性粒细胞与淋巴细胞比值在慢性阻塞性肺疾病中的预测作用

B. Bilir, N. Altintas, M. Aydın, M. Oran, S. Ozsu, Umit Tutar
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引用次数: 14

摘要

目的:近年来,中性粒细胞与淋巴细胞比值(NLR)——反映生理应激后炎症和淋巴细胞发生的严重程度的中性粒细胞水平越来越受欢迎,它与其他炎症标志物一起被普遍认为是炎症状态的准确标志。本研究旨在探讨一种早期、快速、低成本的诊断方法。为此,拟利用慢性阻塞性肺疾病与炎症的相关性,探讨中性粒细胞与淋巴细胞比值能否作为诊断慢性阻塞性肺疾病急性加重期的有效工具。方法:对467例患者进行回顾性研究。对照组为性别、年龄相匹配的健康人,采用c反应蛋白、用力呼气量-1、用力肺活量、全血细胞计数及临床资料进行受体-工作特征曲线分析,确定N/L比和C-Reaktif蛋白预测病情恶化的最佳截断值。双侧p值<0.05认为有统计学意义。结果:经spearman分析,稳定组(r=0.436, p<0.001)和加重组(r=0.534, p=0.001) c -反应蛋白与N/L比值有较强的相关性。结论:中性粒细胞/淋巴细胞比值可能是慢性阻塞性肺疾病患者炎症和慢性阻塞性肺疾病急性加重的有效预测因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Predictive Role of Neutrophil to Lymphocyte ratio in Chronic Obstructive Pulmonary Disease
Objective:Recently neutrophil-to-lymphocyte ratio (NLR) -the level of neutrophil reflecting the severity of inflammation and lymphocyte occurring after physiological stress has been gaining popularity, which was, along with other inflammatory markers, commonly accepted as an accurate marker of the inflammatory status.In this multi-centered study, an early, rapid, and low-cost diagnosis method was investigated. To this end, the correlation between chronic obstructive pulmonary disease and inflammation was planned to be utilized and whether neutrophil-to-lymphocyte ratio can be used as a valid tool in the diagnosis of acute exacerbations of chronic obstructive pulmonary disease was investigated.Method:We retrospectively enrolled the 467 patients. Control group included sex and age-matched healthy people.C-Reactive protein, forced expiratory volume-1, forced vital capacity, complete blood count and clinical data A receiver-operating characteristic curve analysis was performed to determine the best cut-off value of N/L ratio and C-Reaktif protein to predict the exacerbation. Two-sided p values <0.05 were considered statistically significant.Results:By spearman analysis, there was a strong correlation between.C-Reactive protein and N/L ratio in both stable group (r=0.436, p<0.001) and exacerbation group (r=0.534, p=0.001).Conclusion:Neutrophil/lymphocyte ratio may bea useful predictor of inflammation in chronic obstructive pulmonary disease and acute exacarbation of chronic obstructive pulmonary disease patients.
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