Rosiane A. Costa, Daniel B. Ortega, Débora L.A. Fulgêncio, Flávio S. Costa, Thiago F. Araújo, Cristine C. Barreto
{"title":"棋盘试验方法提示培吉肽对多药耐药肺炎克雷伯菌有协同作用","authors":"Rosiane A. Costa, Daniel B. Ortega, Débora L.A. Fulgêncio, Flávio S. Costa, Thiago F. Araújo, Cristine C. Barreto","doi":"10.1016/j.biori.2018.12.001","DOIUrl":null,"url":null,"abstract":"<div><p>Multidrug resistant bacteria infections have motivated the search for new therapeutics. The synergic effect of conventional antibiotics and lipopeptides of the pelgipeptin family was evaluated by the Checkerboard method. Results indicate that the association of Pelgipeptin B and C or chloramphenicol has a synergic effect against a multidrug resistant bacteria strain; which may be may be due to the variations on hydrophobicity and mechanisms of action of the molecules tested.</p></div>","PeriodicalId":100187,"journal":{"name":"Biotechnology Research and Innovation","volume":"3 1","pages":"Pages 187-191"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biori.2018.12.001","citationCount":"15","resultStr":"{\"title\":\"Checkerboard testing method indicates synergic effect of pelgipeptins against multidrug resistant Klebsiella pneumoniae\",\"authors\":\"Rosiane A. Costa, Daniel B. Ortega, Débora L.A. Fulgêncio, Flávio S. Costa, Thiago F. Araújo, Cristine C. Barreto\",\"doi\":\"10.1016/j.biori.2018.12.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Multidrug resistant bacteria infections have motivated the search for new therapeutics. The synergic effect of conventional antibiotics and lipopeptides of the pelgipeptin family was evaluated by the Checkerboard method. Results indicate that the association of Pelgipeptin B and C or chloramphenicol has a synergic effect against a multidrug resistant bacteria strain; which may be may be due to the variations on hydrophobicity and mechanisms of action of the molecules tested.</p></div>\",\"PeriodicalId\":100187,\"journal\":{\"name\":\"Biotechnology Research and Innovation\",\"volume\":\"3 1\",\"pages\":\"Pages 187-191\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.biori.2018.12.001\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biotechnology Research and Innovation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2452072118300613\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biotechnology Research and Innovation","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452072118300613","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Checkerboard testing method indicates synergic effect of pelgipeptins against multidrug resistant Klebsiella pneumoniae
Multidrug resistant bacteria infections have motivated the search for new therapeutics. The synergic effect of conventional antibiotics and lipopeptides of the pelgipeptin family was evaluated by the Checkerboard method. Results indicate that the association of Pelgipeptin B and C or chloramphenicol has a synergic effect against a multidrug resistant bacteria strain; which may be may be due to the variations on hydrophobicity and mechanisms of action of the molecules tested.
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