野生型转甲状腺素淀粉样变性心肌病患者的心脏图像、生物标记物和淀粉样负荷之间的相关性

Mami Morioka, Seiji Takashio, Naoya Nakashima, Masato Nishi, Akira Fujiyama, Kyoko Hirakawa, Shinsuke Hanatani, Hiroki Usuku, Eiichiro Yamamoto, Masafumi Kidoh, Seitaro Oda, Kenichi Matsushita, Mitsuharu Ueda, Kenichi Tsujita
{"title":"野生型转甲状腺素淀粉样变性心肌病患者的心脏图像、生物标记物和淀粉样负荷之间的相关性","authors":"Mami Morioka, Seiji Takashio, Naoya Nakashima, Masato Nishi, Akira Fujiyama, Kyoko Hirakawa, Shinsuke Hanatani, Hiroki Usuku, Eiichiro Yamamoto, Masafumi Kidoh, Seitaro Oda, Kenichi Matsushita, Mitsuharu Ueda, Kenichi Tsujita","doi":"10.1161/JAHA.121.024717","DOIUrl":null,"url":null,"abstract":"<p><p>Background Several imaging parameters and biomarkers provide diagnostic and prognostic information for wild-type transthyretin amyloid cardiomyopathy. However, the relevance of these parameters and their association with cardiac amyloid load requires further substantiation. We aimed to elucidate the association of imaging parameters obtained using <sup>99m</sup>Tc-labeled pyrophosphate scintigraphy, cardiovascular magnetic resonance imaging, global longitudinal strain (GLS), and cardiac biomarkers with cardiac amyloid load in patients with wild-type transthyretin amyloid cardiomyopathy. Methods and Results Eighty-eight patients with wild-type transthyretin amyloid cardiomyopathy who underwent <sup>99m</sup>Tc-labeled pyrophosphate scintigraphy and cardiovascular magnetic resonance were retrospectively evaluated. Quantitative cardiac amyloid load was obtained from 61 patients after myocardial biopsy. Correlations were assessed using Pearson's correlation coefficient applied to medical record data. The mean heart to contralateral ratio, native T1, extracellular volume, and GLS were 1.91±0.36, 1419.4±56.4 ms, 56.5±13.6%, and -9.4±2.5%, respectively. Median high-sensitivity cardiac troponin T (hs-cTnT) and BNP (B-type natriuretic peptide) levels were 0.0478 (0.0334-0.0691) ng/mL and 213.8 (125.8-392.7) pg/mL, respectively. The mean cardiac amyloid load was 22.9±15.0%. The heart to contralateral ratio correlated significantly with native T1 (<i>r</i>=0.397), extracellular volume (<i>r</i>=0.477), GLS (<i>r</i>=0.363), cardiac amyloid load (<i>r</i>=0.379), and Ln (hs-cTnT) (<i>r</i>=0.247). Further, cardiac amyloid load correlated significantly with native T1 (<i>r</i>=0.509), extracellular volume (<i>r</i>=0.310), GLS (<i>r</i>=0.446), and Ln (hs-cTnT) (<i>r</i>=0.354). Compared with BNP, hs-cTnT levels better correlated with several imaging parameters and cardiac amyloid load. Conclusions Increased cardiac amyloid load correlated with increased <sup>99m</sup>Tc-labeled pyrophosphate positivity, native T1, extracellular volume, and hs-cTnT levels, and an impaired GLS, suggesting that imaging parameters and cardiac biomarkers may reflect histological and functional changes attributable to amyloid deposition in the myocardium.</p>","PeriodicalId":17189,"journal":{"name":"Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238652/pdf/","citationCount":"0","resultStr":"{\"title\":\"Correlation Between Cardiac Images, Biomarkers, and Amyloid Load in Wild-Type Transthyretin Amyloid Cardiomyopathy.\",\"authors\":\"Mami Morioka, Seiji Takashio, Naoya Nakashima, Masato Nishi, Akira Fujiyama, Kyoko Hirakawa, Shinsuke Hanatani, Hiroki Usuku, Eiichiro Yamamoto, Masafumi Kidoh, Seitaro Oda, Kenichi Matsushita, Mitsuharu Ueda, Kenichi Tsujita\",\"doi\":\"10.1161/JAHA.121.024717\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Background Several imaging parameters and biomarkers provide diagnostic and prognostic information for wild-type transthyretin amyloid cardiomyopathy. However, the relevance of these parameters and their association with cardiac amyloid load requires further substantiation. We aimed to elucidate the association of imaging parameters obtained using <sup>99m</sup>Tc-labeled pyrophosphate scintigraphy, cardiovascular magnetic resonance imaging, global longitudinal strain (GLS), and cardiac biomarkers with cardiac amyloid load in patients with wild-type transthyretin amyloid cardiomyopathy. Methods and Results Eighty-eight patients with wild-type transthyretin amyloid cardiomyopathy who underwent <sup>99m</sup>Tc-labeled pyrophosphate scintigraphy and cardiovascular magnetic resonance were retrospectively evaluated. Quantitative cardiac amyloid load was obtained from 61 patients after myocardial biopsy. Correlations were assessed using Pearson's correlation coefficient applied to medical record data. The mean heart to contralateral ratio, native T1, extracellular volume, and GLS were 1.91±0.36, 1419.4±56.4 ms, 56.5±13.6%, and -9.4±2.5%, respectively. Median high-sensitivity cardiac troponin T (hs-cTnT) and BNP (B-type natriuretic peptide) levels were 0.0478 (0.0334-0.0691) ng/mL and 213.8 (125.8-392.7) pg/mL, respectively. The mean cardiac amyloid load was 22.9±15.0%. The heart to contralateral ratio correlated significantly with native T1 (<i>r</i>=0.397), extracellular volume (<i>r</i>=0.477), GLS (<i>r</i>=0.363), cardiac amyloid load (<i>r</i>=0.379), and Ln (hs-cTnT) (<i>r</i>=0.247). Further, cardiac amyloid load correlated significantly with native T1 (<i>r</i>=0.509), extracellular volume (<i>r</i>=0.310), GLS (<i>r</i>=0.446), and Ln (hs-cTnT) (<i>r</i>=0.354). Compared with BNP, hs-cTnT levels better correlated with several imaging parameters and cardiac amyloid load. Conclusions Increased cardiac amyloid load correlated with increased <sup>99m</sup>Tc-labeled pyrophosphate positivity, native T1, extracellular volume, and hs-cTnT levels, and an impaired GLS, suggesting that imaging parameters and cardiac biomarkers may reflect histological and functional changes attributable to amyloid deposition in the myocardium.</p>\",\"PeriodicalId\":17189,\"journal\":{\"name\":\"Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-06-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238652/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1161/JAHA.121.024717\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/6/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1161/JAHA.121.024717","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/6/14 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景 一些成像参数和生物标志物为野生型转甲状腺素淀粉样变性心肌病提供了诊断和预后信息。然而,这些参数的相关性及其与心脏淀粉样蛋白负荷的关系还需要进一步证实。我们旨在阐明野生型转甲状腺素淀粉样变性心肌病患者中使用 99mTc 标记的焦磷酸闪烁成像、心血管磁共振成像、整体纵向应变(GLS)和心脏生物标志物获得的成像参数与心脏淀粉样负荷的关联。方法与结果 对接受 99mTc 标记焦磷酸闪烁成像和心血管磁共振检查的 88 例野生型转甲状腺素淀粉样变性心肌病患者进行了回顾性评估。对61名患者进行心肌活检后,获得了定量的心脏淀粉样蛋白负荷。相关性采用皮尔逊相关系数对病历数据进行评估。心脏与对侧比率、原生T1、细胞外体积和GLS的平均值分别为1.91±0.36、1419.4±56.4 ms、56.5±13.6%和-9.4±2.5%。高敏心肌肌钙蛋白T(hs-cTnT)和BNP(B型钠尿肽)的中位水平分别为0.0478(0.0334-0.0691)纳克/毫升和213.8(125.8-392.7)皮克/毫升。平均心脏淀粉样蛋白负荷为22.9±15.0%。心脏与对侧比率与原生T1(r=0.397)、细胞外体积(r=0.477)、GLS(r=0.363)、心脏淀粉样蛋白负荷(r=0.379)和Ln(hs-cTnT)(r=0.247)显著相关。此外,心脏淀粉样蛋白负荷与原生 T1(r=0.509)、细胞外体积(r=0.310)、GLS(r=0.446)和 Ln(hs-cTnT)(r=0.354)显著相关。与 BNP 相比,hs-cTnT 水平与几个成像参数和心脏淀粉样蛋白负荷的相关性更好。结论 心脏淀粉样蛋白负荷的增加与 99mTc 标记的焦磷酸阳性率、原生 T1、细胞外容积和 hs-cTnT 水平的增加以及 GLS 的受损相关,表明成像参数和心脏生物标志物可反映淀粉样蛋白沉积在心肌中引起的组织学和功能变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation Between Cardiac Images, Biomarkers, and Amyloid Load in Wild-Type Transthyretin Amyloid Cardiomyopathy.

Background Several imaging parameters and biomarkers provide diagnostic and prognostic information for wild-type transthyretin amyloid cardiomyopathy. However, the relevance of these parameters and their association with cardiac amyloid load requires further substantiation. We aimed to elucidate the association of imaging parameters obtained using 99mTc-labeled pyrophosphate scintigraphy, cardiovascular magnetic resonance imaging, global longitudinal strain (GLS), and cardiac biomarkers with cardiac amyloid load in patients with wild-type transthyretin amyloid cardiomyopathy. Methods and Results Eighty-eight patients with wild-type transthyretin amyloid cardiomyopathy who underwent 99mTc-labeled pyrophosphate scintigraphy and cardiovascular magnetic resonance were retrospectively evaluated. Quantitative cardiac amyloid load was obtained from 61 patients after myocardial biopsy. Correlations were assessed using Pearson's correlation coefficient applied to medical record data. The mean heart to contralateral ratio, native T1, extracellular volume, and GLS were 1.91±0.36, 1419.4±56.4 ms, 56.5±13.6%, and -9.4±2.5%, respectively. Median high-sensitivity cardiac troponin T (hs-cTnT) and BNP (B-type natriuretic peptide) levels were 0.0478 (0.0334-0.0691) ng/mL and 213.8 (125.8-392.7) pg/mL, respectively. The mean cardiac amyloid load was 22.9±15.0%. The heart to contralateral ratio correlated significantly with native T1 (r=0.397), extracellular volume (r=0.477), GLS (r=0.363), cardiac amyloid load (r=0.379), and Ln (hs-cTnT) (r=0.247). Further, cardiac amyloid load correlated significantly with native T1 (r=0.509), extracellular volume (r=0.310), GLS (r=0.446), and Ln (hs-cTnT) (r=0.354). Compared with BNP, hs-cTnT levels better correlated with several imaging parameters and cardiac amyloid load. Conclusions Increased cardiac amyloid load correlated with increased 99mTc-labeled pyrophosphate positivity, native T1, extracellular volume, and hs-cTnT levels, and an impaired GLS, suggesting that imaging parameters and cardiac biomarkers may reflect histological and functional changes attributable to amyloid deposition in the myocardium.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信