铜催化合成β-和δ-碳胺的高效方法研究

Phuc Van Ban, Quan M. Nguyen, Hien M. Nguyen, Tien Quyet Nguyen, Nga Thi Thanh Truong, Tuan Ngoc Nguyen, A. Nguyen, Hanh Hong Cu, Tuan Dang Thanh, Hung Quang Hung
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引用次数: 0

摘要

2,3-二溴吡啶和3,4-二溴吡啶两步反应合成β-和δ-卡波林的方法。以邻溴苯硼酸为底物,通过位点选择性Suzuki-Myaura反应制备中间体,然后在铜催化剂下与相应的胺进行Ulmann双C-N偶联反应得到最终产物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research on efficient synthetic method of β- and δ-carbolines using a Copper catalyst
Methodology for synthesizing of β- and δ-carboline via two steps reaction from 2,3-dibromopyridine and 3,4-dibromopyridine. The intermediate was prepared from the substrate with o-bromophenylboronic acid via site-selective Suzuki-Myaura reaction, then, the final products were obtained by double C-N coupling via the Ulmann reaction of the intermediate with the corresponding amine with copper catalyst.
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