动态细胞形态变化的定量分析方法

Xing An, Zhiwen Liu, Chuanfeng Lv, Yonggang Shi
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引用次数: 1

摘要

近年来,随着显微成像技术的进步,细胞形态学分析已成为生物医学图像处理领域的一个重要分支。细胞图像分析作为临床信息获取的辅助手段,在癌症、白血病等重大疾病的正确诊断和治疗中发挥了重要作用。该领域的早期研究主要集中在静止图像信息上,主要关注细胞计数或细胞图像的形态特征。此外,对细胞图像的形态学变化进行定性分析的研究较多,而对其进行定量分析的研究较少,而定量分析实际上更有效、客观和准确。在这种情况下,我们的工作集中在用定量测量的方法分析细胞形态的变化,并提出了一种新的方法——周长径向差(Rdc)。其基本思想是通过估算360个不同角度的径向差异来测量形态变化。利用合作医院提供的两套淋巴细胞视频数据库对所提出的方法进行验证。实验结果表明,所提出的Rdc测量方法与人们的主观判断具有较好的一致性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Method of Quantitative Analysis for Dynamic Cellular Morphological Change
In recent years, with the advancement of micro- scopic imaging technique, cellular morphological analysis has become one of the most important branches of biomedical image processing field. Cell image analysis, an assisting method of clinical information acquisition, has played an important role in facilitating the appropriate diagnosis and treatment against some serious diseases such as cancer, leukemia and etc. Early studies of this field focuses on still image information and mainly concerns either cell counting or the morphological characteristics of cell image. Furthermore, much effort has been devoted to analyzing the morphological change of cell image qualitatively, while less attention has been paid to analyzing it quantitatively which in fact is more effective, objective and accurate. Under this very circumstances, our work concentrates on analyzing the cellular morphological change by means of quantitative measurement, and a new method—circumference radial difference (Rdc )i s pro- posed. The basic idea is to measure the morphological change by estimating the radial differences from 360 different angles. Two sets of lymphocyte video database provided by the cooperation hospital are used to verify the proposed approach. Experimental results show that the proposed (Rdc) measurement can produce reasonably good agreement with subjective judgment by people.
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