Current status of surgery for osteogenesis imperfecta

Osteogenesis imperfecta (OI) is a congenital hereditary connective tissue disease caused by mesenchymal tissue hypoplasia and collagen formation disorder.Fragile bones often lead to repeated fractures along with long-bone deformities and scoliosis.The surgical objective is to fix fractures, correct long-bone deformities, boost the strength of fragile bones and treat scoliosis.Although some efficacies have been achieved, there is no uniform standard and controversies focus upon the timing and choice of surgical approaches.Through summarizing the relevant articles over the last two decades, this review discussed the development and current status of surgery for OI, summarized the achievements and controversies of surgery for long-bone deformity and scoliosis and introduced the implication of weight-loss surgery for OI. Key words: Osteogenesis imperfecta; Surgical procedures, operative; Weight-loss surgery