Effect of an Aqueous Extract of Fenugreek (Trigonella Foenum Graecum) seeds on Hyperglycemia Induced with Alloxan

Background: Diabetes mellitus is a metabolic disease that causes high blood sugar. The number of people suffering from the disease worldwide is increasing at an alarming rate. Fenugreek ( Trigonella foenum-graecum ) is an herb long used in alternative medicine. This herb has many health benefits. These benefits may be due to fenugreek’s role in improving insulin function. Objectives: To evaluate antidiabetic effects of Fenugreek seeds extract on Alloxan-induced diabetic mice. Methods: The total of 30 mice (n=10) were grouped randomly into 3 groups as followings: Group I: Normal control (NC), Group II: Diabetic control (DC) and Group III: Treatment Diabetic Group (DT). Mice were injected with subcutaneous injection 180mg/kg body of freshly prepared of Alloxan and Diabetes mellitus confirmed by testing blood glucose, and mice with blood glucose level of ≥200mg/dl were considered as diabetic. Diabetic mice were received 10mg/kg of body weight from fenugreek extract. Result: All Diabetic mice that received extract showed a significant decrease in blood sugar (P<0.01). Conclusion: Fenugreek seeds reduce blood sugar levels.