COVID-19 Delta 变体--截至 2021 年 8 月的现状和影响。

IF 5.1 4区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Precision Clinical Medicine Pub Date : 2021-09-20 eCollection Date: 2021-12-01 DOI:10.1093/pcmedi/pbab024

Flora Yu, Lok-Ting Lau, Manson Fok, Johnson Yiu-Nam Lau, Kang Zhang

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引用次数: 0

摘要

SARS-CoV-2 Delta 变异株已演变为当前大流行病的主要病毒株。研究表明，这种变异株的感染性/病毒载量增加，康复病人/疫苗接种者宿主抗体的中和能力降低。临床上，在康复期病人/疫苗接种者中也观察到/记录到了德尔塔变异株感染，虽然严重疾病的发病率较低，但可成为向未接种疫苗者传播感染的储库。本微型综述将讨论目前（截至 2021 年 8 月 18 日）对病毒学方面（包括氨基酸替代）、临床影响和公共卫生影响的理解，并向卫生当局提出建议。

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COVID-19 Delta variants-Current status and implications as of August 2021.

The SARS-CoV-2 Delta variant has evolved as the dominant strain of the current pandemic. Studies have shown that this variant has increased infectivity/viral load, and reduced neutralization by the host antibodies from convalescent patients/vaccinees. Clinically, Delta variant infection has been observed/documented in convalescent patients/vaccinees, although with less incidence of severe diseases, but can serve as reservoir to spread the infection to the unvaccinated. The current understanding (as of 18 August 2021) on the virologic aspect (including the amino acid substitutions), clinical implications, and public health implications will be discussed in this mini review, and recommendations to health authorities will be provided.

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来源期刊

Precision Clinical Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

10.80

自引率

0.00%

发文量

审稿时长

5 weeks

期刊介绍： Precision Clinical Medicine (PCM) is an international, peer-reviewed, open access journal that provides timely publication of original research articles, case reports, reviews, editorials, and perspectives across the spectrum of precision medicine. The journal's mission is to deliver new theories, methods, and evidence that enhance disease diagnosis, treatment, prevention, and prognosis, thereby establishing a vital communication platform for clinicians and researchers that has the potential to transform medical practice. PCM encompasses all facets of precision medicine, which involves personalized approaches to diagnosis, treatment, and prevention, tailored to individual patients or patient subgroups based on their unique genetic, phenotypic, or psychosocial profiles. The clinical conditions addressed by the journal include a wide range of areas such as cancer, infectious diseases, inherited diseases, complex diseases, and rare diseases.