{"title":"色氨酸辅助治疗常规氟哌啶醇治疗精神分裂症:对大鼠脑中血清素能机制的影响","authors":"F. Batool, D. Haleem","doi":"10.5580/14d2","DOIUrl":null,"url":null,"abstract":"We studied the effects of dietary amino acid L-tryptophan (TRP) as an adjunct to haloperidol administration on the modulation of extrapyramidal symptoms (EPS) and rat brain serotonin (5-hydroxytryptamine; 5-HT) functions in relation to schizophrenia. TRP added in the drinking water and haloperidol at doses of 5.0 mg/kg or saline were injected for two weeks twice daily with one week of withdrawal to 36 locally bred male albino Wistar rats. Motor/ Exploratory activities were scored in activity boxes and open field apparatuses. Catalepsy was monitored on an inclined surface. Results revealed significant increases (p<0.01) in locomotor activity and marked reduction in catalepsy in rats orally supplemented with TRP for 3 weeks plus haloperidol administration. Significant (p<0.01) increases were observed in the rat brain TRP and 5-HT metabolism. The findings suggest that amino acids, in particular, TRP can possibly attenuate EPS functions induced by haloperidol and enhanced brain 5-HT metabolism.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"3 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tryptophan Adjunctive Therapy To Conventional Haloperidol Treatment In Schizophrenia: Effects On Serotonergic Mechanisms In Rat Brain\",\"authors\":\"F. Batool, D. Haleem\",\"doi\":\"10.5580/14d2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We studied the effects of dietary amino acid L-tryptophan (TRP) as an adjunct to haloperidol administration on the modulation of extrapyramidal symptoms (EPS) and rat brain serotonin (5-hydroxytryptamine; 5-HT) functions in relation to schizophrenia. TRP added in the drinking water and haloperidol at doses of 5.0 mg/kg or saline were injected for two weeks twice daily with one week of withdrawal to 36 locally bred male albino Wistar rats. Motor/ Exploratory activities were scored in activity boxes and open field apparatuses. Catalepsy was monitored on an inclined surface. Results revealed significant increases (p<0.01) in locomotor activity and marked reduction in catalepsy in rats orally supplemented with TRP for 3 weeks plus haloperidol administration. Significant (p<0.01) increases were observed in the rat brain TRP and 5-HT metabolism. The findings suggest that amino acids, in particular, TRP can possibly attenuate EPS functions induced by haloperidol and enhanced brain 5-HT metabolism.\",\"PeriodicalId\":22523,\"journal\":{\"name\":\"The Internet Journal of Pharmacology\",\"volume\":\"3 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet Journal of Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5580/14d2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/14d2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Tryptophan Adjunctive Therapy To Conventional Haloperidol Treatment In Schizophrenia: Effects On Serotonergic Mechanisms In Rat Brain
We studied the effects of dietary amino acid L-tryptophan (TRP) as an adjunct to haloperidol administration on the modulation of extrapyramidal symptoms (EPS) and rat brain serotonin (5-hydroxytryptamine; 5-HT) functions in relation to schizophrenia. TRP added in the drinking water and haloperidol at doses of 5.0 mg/kg or saline were injected for two weeks twice daily with one week of withdrawal to 36 locally bred male albino Wistar rats. Motor/ Exploratory activities were scored in activity boxes and open field apparatuses. Catalepsy was monitored on an inclined surface. Results revealed significant increases (p<0.01) in locomotor activity and marked reduction in catalepsy in rats orally supplemented with TRP for 3 weeks plus haloperidol administration. Significant (p<0.01) increases were observed in the rat brain TRP and 5-HT metabolism. The findings suggest that amino acids, in particular, TRP can possibly attenuate EPS functions induced by haloperidol and enhanced brain 5-HT metabolism.
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