壳聚糖包覆策略在二氧化钛纳米管阵列靶向化学药物递送纳米系统开发中的应用

IF 0.7 4区材料科学 Q4 METALLURGY & METALLURGICAL ENGINEERING

International Journal of Materials Research Pub Date : 2023-08-11 DOI:10.1557/s43578-023-01126-2

Wan Nuramiera Faznie Wan Eddis Effendy, R. B. S. M. N. Mydin, S. Sreekantan, Amirah Mohd Gazzali, R. Hazan, Muhammad Yusri Musa

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引用次数: 0

摘要

本研究从壳聚糖包覆策略，包括包覆方法、包覆层数、生物相容性、CDDP释放等方面考察顺铂(CDDP) -二氧化钛纳米管阵列(TNA)的包覆效率。采用场发射扫描电镜、能量色散x射线、x射线衍射、离子耦合等离子体光学发射光谱、傅里叶变换红外光谱和分光光度法进行表征。结果表明，采用顶部填充法将CDDP高效负载在TNA纳米体系上，包封效率为98.95±7.02%。ICP-OES证实了这一点，该仪器对铂(Pt)离子进行了长达十天的检测。该纳米系统成功地使CDDP在各种受刺激的模型系统中长期持续释放，建立了有效的体外靶向癌症治疗模型。进一步的研究需要使用体内模型来验证这项研究的结果，特别是在靶向癌症治疗应用的背景下。对当前工作的说明性描述。该图详细描述了生物聚合物壳聚糖负载CDDP- dtna (CDDP- tna)涂层策略的工作流程和CDDP的递送效率，特别是针对癌症治疗应用的延长缓释系统。对当前工作的说明性描述。该图详细描述了生物聚合物壳聚糖负载CDDP- dtna (CDDP- tna)涂层策略的工作流程和CDDP的递送效率，特别是针对癌症治疗应用的延长缓释系统。对当前工作的说明性描述。该图详细描述了生物聚合物壳聚糖负载CDDP- dtna (CDDP- tna)涂层策略的工作流程和CDDP的递送效率，特别是针对癌症治疗应用的延长缓释系统。

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Chitosan-coating strategies on the development of targeted chemodrug delivery nanosystem with titania nanotube arrays

This study investigates Cisplatin (CDDP)—titania nanotube arrays (TNA) encapsulation efficiency in terms of chitosan-coating strategies including coating methods, coating layers, biocompatibility, and CDDP release in various stimulated model systems. Characterization was performed using field emission scanning electron microscopy, energy-dispersive X-ray, X-ray diffraction, ion-coupled plasma-optical emission spectrometry, fourier transform infrared spectroscopy, and spectrophotometry. The results demonstrated efficient biocompatible loading of CDDP onto a TNA nanosystem using the top-filling method, with an encapsulation efficiency of 98.95 ± 7.02%. This was confirmed by ICP-OES, which detected platinum (Pt) ions for up to ten days. The nanosystem successfully enabled long-term sustained release of CDDP in various stimulated model systems, establishing an effective in vitro targeted cancer therapy model. Further investigation using in vivo models is necessary to validate the findings of this study, particularly in the context of targeted cancer therapy applications. An illustrative description of the present work. The image depicts the workflow in detail on CDDP-loadedTNA (CDDP-TNA)-coating strategies with biopolymer chitosan and CDDP delivery efficiency,especially in prolonged sustained release system targeted for cancer treatment application. An illustrative description of the present work. The image depicts the workflow in detail on CDDP-loadedTNA (CDDP-TNA)-coating strategies with biopolymer chitosan and CDDP delivery efficiency,especially in prolonged sustained release system targeted for cancer treatment application. An illustrative description of the present work. The image depicts the workflow in detail on CDDP-loadedTNA (CDDP-TNA)-coating strategies with biopolymer chitosan and CDDP delivery efficiency,especially in prolonged sustained release system targeted for cancer treatment application.

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来源期刊

International Journal of Materials Research 工程技术-冶金工程

CiteScore

1.30

自引率

12.50%

发文量

119

审稿时长

6.4 months

期刊介绍： The International Journal of Materials Research (IJMR) publishes original high quality experimental and theoretical papers and reviews on basic and applied research in the field of materials science and engineering, with focus on synthesis, processing, constitution, and properties of all classes of materials. Particular emphasis is placed on microstructural design, phase relations, computational thermodynamics, and kinetics at the nano to macro scale. Contributions may also focus on progress in advanced characterization techniques. All articles are subject to thorough, independent peer review.