抗氧化剂治疗外阴黑病

E. Kiseleva, A. Makhmutkhodzhaev, G. A. Mikheenko
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摘要

的目标。目的研究抗氧化剂琥珀酸乙甲基羟吡啶对光动力治疗外阴黑痣(外阴硬化苔藓)疗效的影响。材料与方法。该研究招募了90名外阴黑病患者,他们被随机分为3组,接受:1)PDT和琥珀酸乙基甲基羟吡啶,PDT开始后1周,持续1个月;2)不含琥珀酸乙基甲基羟吡啶的PDT;3)会阴区低水平激光治疗。动态评价治疗前及治疗后1、6、12个月外阴黑病的临床表现。采用视觉模拟评分法评价外阴瘙痒严重程度。计算LS-A指数判断疾病活动性,应用LS-S指数量化外阴受累面积。PDT治疗外阴黑病的疗效优于低水平激光治疗。在治疗方案中加入琥珀酸乙基甲基羟吡啶改善了PDT的结果,因为在12个月内,73%的接受PDT联合琥珀酸乙基甲基羟吡啶的患者实现了外阴瘙痒的缓解,而只有47%的单独接受PDT的患者(p = 0.042)。治疗1个月后,联合治疗组瘙痒强度为2.0分,单独治疗组瘙痒强度为4.5分(p < 0.001)。接受联合治疗的患者外阴上皮化发生的时间也更早(48±5天,而单独接受PDT治疗的患者为54±3天,p < 0.001)。经过12个月的观察,接受联合治疗的患者的疾病活动性和受影响的外阴面积显著降低(LS-A 4.0;与单独的PDT相比(LS-A 6.5;LS-S 3.0, p分别= 0.004和< 0.001)。在光动力疗法中加入琥珀酸乙基甲基羟吡啶治疗外阴黑病疗效显著,值得推荐。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antioxidants in treatment of kraurosis vulvae
Aim. To study impact of ethylmethylhydroxypyridine succinate, an antioxidant, on the efficacy of photodynamic therapy (PDT) of kraurosis vulvae (vulvar lichen sclerosus).Materials and Methods. The study enrolled 90 patients with kraurosis vulvae who were randomised into 3 groups receiving: 1) PDT and ethylmethylhydroxypyridine succinate 1 week after the start of the PDT for 1 month; 2) PDT without ethylmethylhydroxypyridine succinate; 3) low-level laser therapy on the perineal region. Clinical manifestations of kraurosis vulvae were dynamically assessed before the treatment and 1, 6, and 12 months post treatment. The severity of vulvar itching was evaluated using visual analogue scale. LS-A index was calculated to determine the disease activity, whilst LS-S index was applied to quantify the affected vulvar area.Results. PDT demonstrated higher therapeutic efficacy in treatment of kraurosis vulvae than low-level laser therapy. Addition of ethylmethylhydroxypyridine succinate to the treatment protocol improved the results of PDT, as remission of vulvar itching within 12 months was achieved in 73% of patients who received PDT in conjunction with ethylmethylhydroxypyridine succinate and only in 47% of participants receiving PDT alone (p = 0.042). One month post treatment, the intensity of itching according to visual analogue scale was 2.0 points in patients who received combined treatment and 4.5 points in those receiving PDT alone (p < 0.001). Vulvar epithelialization also occurred earlier in patients receiving combined treatment (48 ± 5 days versus 54 ± 3 days in those receiving PDT alone, p < 0.001). Upon 12 months of observation, disease activity and affected vulvar area were significantly lower in patients receiving combined treatment (LS-A 4.0; LS-S 1.0) as compared to the PDT alone (LS-A 6.5; LS-S 3.0, p = 0.004 and < 0.001, respectively).Conclusion. Addition of ethylmethylhydroxypyridine succinate to photodynamic therapy demonstrated high efficacy against kraurosis vulvae and can be recommended for its treatment.
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