Are exercise-induced changes of fatty acids associated with cardiac hypertrophy in athletes? A pilot study

Abstract Study aim: In this study, we evaluated the effects of acute and chronic exercise on the plasma FAs and their association with cardiac hypertrophy indices. Material and methods: In this pilot study, 15 sedentary and 15 athlete women underwent acute and long-term water aerobic exercise and their plasma FA levels and a number of electrocardiographic parameters, such as left ventricular end-diastolic diameter index (LVEDDI), left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI), and wall thickness were evaluated before and after the exercise program. Results: The acute exercise significantly increased palmitic and oleic acid levels in non-athletes and stearic acid in both groups. However, the same type of exercise decreased linoleic acid only in non-athlete women (p < 0.05). The water aerobics training caused a significant decrease in the levels of palmitic, stearic, and arachidonic acid, SFA/UFA, and ω3/ ω6 ratios and also an increase in α-Linolenic acid and MUFA in non-athletes. We found positive and negative correlations between LVEF with ω3 and SFA/UFA ratio in both groups, respectively. In the non-athlete group, the ω3/ω6 ratio showed negative correlations with LVMI and LVEDDI. Conclusions: The study indicated that the 12-week exercise by sedentary women could make their plasma FAs composition similar to athlete women. Moreover, the plasma FA levels were associated with cardiac hypertrophy indices, showing the importance of FAs in physiological hypertrophy.