{"title":"共同服用二价阳离子矿物质补充剂导致cART病毒学失败和HIV突变:一个案例研究","authors":"Forst Thomas M, Dinges Warren L","doi":"10.36959/695/564","DOIUrl":null,"url":null,"abstract":"Integrase strand transfer inhibitors (INSTIs) are an important component of modern combined antiretroviral therapy (cART). The mechanism of inhibition for these antivirals is dependent on magnesium ion binding during attempted HIV-1 replication. Exogenous supplementation of magnesium or other divalent cation minerals may interfere with successful inhibition of HIV replication.","PeriodicalId":90584,"journal":{"name":"Journal of clinical research in HIV AIDS and prevention","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Coadministration of Divalent Cation Mineral Supplements Causes cART Virologic Failure and HIV Mutagenesis: A Case Study\",\"authors\":\"Forst Thomas M, Dinges Warren L\",\"doi\":\"10.36959/695/564\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Integrase strand transfer inhibitors (INSTIs) are an important component of modern combined antiretroviral therapy (cART). The mechanism of inhibition for these antivirals is dependent on magnesium ion binding during attempted HIV-1 replication. Exogenous supplementation of magnesium or other divalent cation minerals may interfere with successful inhibition of HIV replication.\",\"PeriodicalId\":90584,\"journal\":{\"name\":\"Journal of clinical research in HIV AIDS and prevention\",\"volume\":\"2 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-09-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of clinical research in HIV AIDS and prevention\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36959/695/564\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical research in HIV AIDS and prevention","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36959/695/564","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Coadministration of Divalent Cation Mineral Supplements Causes cART Virologic Failure and HIV Mutagenesis: A Case Study
Integrase strand transfer inhibitors (INSTIs) are an important component of modern combined antiretroviral therapy (cART). The mechanism of inhibition for these antivirals is dependent on magnesium ion binding during attempted HIV-1 replication. Exogenous supplementation of magnesium or other divalent cation minerals may interfere with successful inhibition of HIV replication.
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