在波兰疑似SARS-CoV-2感染患者中检测SARS-CoV-2抗原试验的验证

IF 1.5 4区医学 Q4 IMMUNOLOGY

Central European Journal of Immunology Pub Date : 2022-02-28 DOI:10.5114/ceji.2022.113992

Mateusz Miłosz, Michał Słota, J. Jakubowski, P. Kwiatkowski, S. Kasperczyk, Małgorzata Kozłowska, B. Pawłowska, Patryk Matuszek, Ewa Kuta

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引用次数: 2

摘要

2019年12月，世界卫生组织(WHO)报告称，中国武汉出现了不明原因肺炎积聚。根据世卫组织的建议，在严格定义的情况下，可以将抗原检测纳入诊断算法，以减少进行的分子检测次数，并支持快速识别和治疗COVID-19患者。根据世卫组织的建议，与分子检测(NAAT)相比，用于诊断的抗原检测应具有≥80%的敏感性和≥97%的特异性。通过对比分析，确定RT-PCR参比法的SARS-CoV-2抗原ELISA检测的敏感性和特异性。SARS-CoV-2抗原ELISA检测灵敏度为100%(51/51)，特异性为98.84%。获得的数据表明，所分析的抗原检测符合世界卫生组织和卫生部的标准。

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Validation of the test for detecting SARS--CoV-2 antigens in the Polish population in patients with suspected SARS-CoV-2 infection

In December 2019, the World Health Organization (WHO) reported that China had accumulated pneumonia of unclear etiology in Wuhan. According to WHO recommendations, in strictly defined situations, antigen tests can be implemented into the diagnostic algorithm to reduce the number of molecular tests performed and support the rapid identification and treatment of COVID-19 patients. According to WHO recommendations, the antigen test for diagnostic use should have a sensitivity of ≥ 80% and a specificity of ≥ 97% compared to molecular tests (NAAT). Based on the comparative analysis, the sensitivity and specificity of the SARS-CoV-2 Antigen ELISA test were determined concerning the RT-PCR reference method. The sensitivity of the SARS-CoV-2 Antigen ELISA was 100% (51/51) and the specificity was 98.84%. The obtained data demonstrate that the analyzed antigen test meets both the WHO and the Ministry of Health criteria.

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来源期刊

Central European Journal of Immunology IMMUNOLOGY-

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Central European Journal of Immunology is a English-language quarterly aimed mainly at immunologists.