骨髓组织化学c-mpl阳性能否作为免疫性血小板减少症患者脾切除术的预测指标?

I. Yavaşoğlu, Nadide Gencer, Fulden Cantaş, F. Doğer, Z. Bolaman
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引用次数: 0

摘要

目的:脾切除术是免疫性血小板减少症(ITP)患者的二线治疗方法。然而,没有参数预测脾切除术的决定。血小板生成素通过其受体c-mpl调节血小板计数。本研究的目的是评估免疫组织化学克隆髓系白血病病毒(c-mpl)阳性的ITP患者骨髓标本有或没有脾切除指征。方法:取24例行脾切除术的ITP患者脾切除术前骨髓标本和30例未行脾切除术的ITP患者骨髓标本进行c-mpl染色。结果:脾切除术患者(n: 23) c-mpl阴性高于未脾切除术患者(n:18)。脾切除术前后血小板计数有显著差异。我们的研究显示,未行脾切除术的患者组c-mpl阳性有统计学意义。在行脾切除术的患者组中,c-mpl与难治性状态无关。结论:c-mpl阴性水平可作为免疫性血小板减少症脾切除指征的参考指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Can Histochemical c-mpl Positivity in Bone Marrow be a Predictor for Splenectomy in Immune Thrombocytopenia?
Purpose: Splenectomy is used as the second line therapy in patients with immune thrombocytopenia (ITP). However, there is no parameter predicting splenectomy decision. Thrombopoietin is the main regulator of platelet count through its receptor c-mpl. The aim of the present study was to evaluate immune histochemical Cloned Myeloid Leukemia Virus (c-mpl) positivity in bone marrow specimens of ITP patients with or without splenectomy indications. Methods: Pre-splenectomy bone marrow was stained for c-mpl, that was taken from 24 patients with ITP and who had splenectomy as well as bone marrow samples from 30 patients with ITP who did not have splenectomy. Results: c-mpl negativity was higher in splenectomized patients (n: 23) compared to patients without splenectomy (n:18). A significant difference was found for platelet counts before and after splenectomy. Our study show that, c-mpl positivity was statistically significant in patient group who did not have splenectomy. In the patient group who had the splenectomy, c-mpl was not associated with refractory status.  Conclusion: The significant level of c-mpl negativity might be the useful parameter for splenectomy indication in patients with immune thrombocytopenia.
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