苯并咪唑衍生物的绿色合成:绿色化学及其应用综述

IF 3.5 Q2 CHEMISTRY, MULTIDISCIPLINARY
M. Asif
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引用次数: 6

摘要

我们环境中的化学物质日益增多。其中只有一部分是可降解的,但大多数是不可降解的。这些不可降解的物质会产生污染,对生态系统造成不稳定、伤害或不适,并对环境造成风险。为了减少一种制度的可能性,我们必须通过改变原因而不是改变结果来减少风险。因此,绿色化学(GC)的概念被引入,是一个新兴的化学领域。GC是设计化学产品和程序,以减少或消除有害物质的使用和生产。近年来,各种各样的杂环化合物由于其药理活性的广泛变化而出现。苯并咪唑是一种杂环芳香化合物。它是药物化学中一种重要的优势结构,具有镇痛、抗炎、抗溃疡、降压、抗菌、抗病毒、抗真菌、抗癌、抗组胺等丰富的治疗活性。由于其价值,其合成工艺已成为合成化学家关注的焦点。因此,本文综述了不同取代的苯并咪唑的化学性质和其他一些方法。传统的合成方法需要较长的加热时间,设备设置复杂繁琐,成本高,污染大,而绿色合成方法则价格低廉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Green Synthesis of Benzimidazole Derivatives: an Overview on Green Chemistry and Its Applications
The chemical substances in our environment are rising day by day. Only some of them are degraded, but most of them are non-degradable. These non-degradable substances produce pollutions which cause instability, harm or discomfort to the ecosystem as pollutions and create a risk to the environment. To reduce the possibility of a system we must reduce the risk not by altering the effect but by the cause. Thus, green chemistry (GC) concept was introduced, and it is a rapidly emerging field of chemistry. The GC is the design of chemical products and procedures that decrease or remove the use and production of harmful substances. In recent years, various heterocyclic compounds have appeared owing to the extensive varieties of their pharmacological activities. Benzimidazole is a heterocyclic aromatic compound. It is a vital and advantaged structure in medicinal chemistry and plays a role with ample therapeutic activities like analgesic, anti-inflammatory, antiulcer, antihypertensive, antibacterial, antiviral, antifungal, anticancer and antihistaminic. Because of its value, the processes for their synthesis have become a focus of synthetic chemists. Therefore, this review aims at compiling the chemistry of differently substituted benzimidazoles and some other methods. Conventional methods of synthesis need longer heating time, complicated and tedious apparatus set up which result in high cost and pollution in contrast to greener methods which are inexpensive.
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来源期刊
Chemical Methodologies
Chemical Methodologies CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
3.10
自引率
1.80%
发文量
8
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