电子烟含CBD液体:精神药物和次级大麻素的形成以及吸烟过程中幸存的CBD数量

IF 1.4 4区 医学 Q3 MEDICINE, LEGAL
Andrea Capucciati, Arianna Bini, B. Mannucci, A. Porta, A. Profumo, D. Merli
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引用次数: 0

摘要

最近,由于大麻二酚(CBD)的治疗潜力,人们对它的兴趣越来越大,含有CBD的电子烟液体在市场上激增。通常,电子液体在丙二醇或丙二醇:甘油70:30的混合物中含有不同浓度的CBD(从2mg∙mL−1到20mg∙mL−1),并最终以食品级香料调味。在这项工作中,通过对真实电子烟产生的冷凝烟雾进行气相色谱-质谱分析,我们已经证明了吸烟过程中可以存活的CBD的实际数量,并且我们发现在吸烟过程中形成的THCs数量可以忽略不计(即,形成的数量<0.005 mg每mg蒸发的CBD);考虑到∆9-THC的阈值剂量约为2.5毫克(吸烟或摄入),可以合理地得出结论,意外的THC中毒是不太可能的,从法医的角度来看,这是一个非常重要的问题,因为在一些法庭案件中,使用含有CBD的电子烟液体被认为是THC中毒的来源。此外,本研究中考虑的所有其他大麻素以及可能来自CBD热降解的大麻素浓度均低于仪器LOD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CBD-Containing Liquids for e-Cigarettes: Formation of Psychotropic and Secondary Cannabinoids and Amount of CBD Surviving the Smoking Procedure
Recently, as the interest in cannabidiol (CBD) has grown due to its therapeutic potential, e-cigarette liquids containing CBD have proliferated on the market. Typically, e-liquids contain variable concentrations of CBD (from 2 mg∙mL−1 to 20 mg∙mL−1) in propylene glycol or 70:30 propylene glycol:glycerol mixture and are eventually flavored with food-grade flavors. In this work, carried out by a GC-MS analysis of the condensed smoke produced by a real e-cig, we have demonstrated the actual amount of CBD that can survive the smoking process, and we found that negligible amounts of THCs are formed during the smoking process (i.e., the amount formed was <0.005 mg for each mg of vaped CBD); considering that the threshold dose for ∆9-THC is around 2.5 mg (smoked or ingested per os), it is reasonable to conclude that accidental THC intoxication is unlikely, which is a very important issue from a forensic point of view, as in some court cases the use of e-cig liquids containing CBD has been argued as being the source of THC intoxication. Furthermore, all the other cannabinoids considered in this study and potentially derived from CBD thermal degradation have concentrations below the instrumental LOD.
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来源期刊
Forensic Sciences Research
Forensic Sciences Research MEDICINE, LEGAL-
CiteScore
3.60
自引率
7.70%
发文量
158
审稿时长
26 weeks
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