新生隐球菌具有抗吞噬特性的吞噬细胞之间的相互作用:当爱与恨碰撞时

F. E. Siagian
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引用次数: 0

摘要

全球系统性真菌感染,包括由包膜酵母隐球菌引起的脑膜炎隐球菌病,数量继续上升,特别是在艾滋病毒感染者中。感染是通过吸入环境中丰富的孢子而发生的。最初,这种真菌在肺部停留一段时间而不会引起任何症状,当宿主的细胞免疫状态耗尽时,它可以利用单核细胞作为载体将它们带到大脑,使用一种称为特洛伊木马机制的机制。正常肺泡巨噬细胞作为肺内先天免疫系统的第一道防线,在吞噬溶酶体的细胞器内进行吞噬、内化和破坏。但隐球菌似乎有一个内置的抗吞噬机制,以避免破坏,甚至可以在其中繁殖。这种聪明的酵母菌和宿主的吞噬细胞之间的相互作用决定了疾病的进程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interaction between Phagocytic Cells with Antiphagocytic Properties of Cryptococcus neoformans: When Love and Hate Collide
Global systemic fungal infection, including meningeal cryptococcosis caused by the encapsulated yeast Cryptococcus spp, continue to rise in number, especially among HIV infected individuals. Infection occur through inhalation of spore which is abundant in the environment. Initially this fungus stay in the lungs for a certain time without causing any symptoms and when the host’s cellular immune status is depleted, it can uses monocyte as a vehicle to take them to the brain, using a mechanism called Trojan Horse mechanism. Normal alveolar macrophage as the first line of innate immune system in the lungs are supposed to phagocytose, internalized and then destroy it inside an organelle named phagolysosome. But Cryptococcus spp seemed to have a built in antiphagocytic mechanism to avoid destruction and even can multiply therein. The interaction between this clever yeast and the host’s phagocytic cells determine the course of the disease.
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