液体活检:治疗学和个体化肿瘤学

Akash S. Mali, Shravni Gosavi, G. Shukla
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引用次数: 0

摘要

癌症与基因突变有关,对肿瘤相关基因改变的研究逐渐用于诊断和治疗目的。实体瘤现在从活检和/或手术或活检标本中获得。肿瘤细胞将循环的游离DNA释放到血液中,但大多数循环DNA往往不是癌源的,血液中癌症相关等位基因的检测长期以来难以实现。现代科学已经突破了这些限制,使识别遗传和表观遗传畸变成为可能。液体活检(LB)或血液样本可以提供所有癌症病变(原发性和转移性)的遗传图谱,并提供系统跟踪基因组进化的机会。本次交流将探讨LB如何与个性化肿瘤学相关联,以预测对治疗的反应和获得性耐药的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
LIQUID BIOPSY: THERANOSTICS AND PERSONALIZED ONCOLOGY
Cancer is linked with mutated genes, and the study of tumor-associated genetic alterations is gradually used for diagnostic and treatment purposes. The solid tumors are now obtained from biopsy and/or surgical or biopsy specimens. Tumor cells release circulating free DNA into the blood, but the majority of circulating DNA are often not of cancerous origin, and the detection of cancer-associated alleles in the blood has long been unbearable to achieve. Modern science has overwhelmed these restrictions, making it possible to identify both genetic and epigenetic aberrations. A liquid biopsy (LB) or blood sample can provide the genetic landscape of all cancerous lesions (primary and metastases) as well as offering the opportunity to systematically track genomic evolution. This communication will explore how LB is associated with personalized oncology to predict response to treatments and the development of acquired resistance.
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