新发现的金黄色葡萄球菌丝氨酸水解酶探针及药物靶点

IF 3.4 Q2 CHEMISTRY, MEDICINAL

ADMET and DMPK Pub Date : 2021-10-28 DOI:10.5599/admet.1137

M. Fellner

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引用次数: 2

摘要

对于细菌病原体金黄色葡萄球菌，迫切需要新的诊断和治疗方案。本文综述了最近发现的10种与生物膜相关的丝氨酸水解酶，即氟膦酸结合水解酶(FphA-J)。根据总结的发现，许多这些蛋白质代表了探针和药物开发的有趣的新靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Newly discovered Staphylococcus aureus serine hydrolase probe and drug targets

There is an urgent need for new diagnosis and treatment options for the bacterial pathogen Staphylococcus aureus. This review will summarize data on ten recently discovered biofilm-associated serine hydrolases called fluorophosphonate-binding hydrolases (FphA-J). Based on the summarized findings, many of these proteins represent intriguing new targets for probe and drug development.

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来源期刊

ADMET and DMPK Multiple-

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： ADMET and DMPK is an open access journal devoted to the rapid dissemination of new and original scientific results in all areas of absorption, distribution, metabolism, excretion, toxicology and pharmacokinetics of drugs. ADMET and DMPK publishes the following types of contributions: - Original research papers - Feature articles - Review articles - Short communications and Notes - Letters to Editors - Book reviews The scope of the Journal involves, but is not limited to, the following areas: - physico-chemical properties of drugs and methods of their determination - drug permeabilities - drug absorption - drug-drug, drug-protein, drug-membrane and drug-DNA interactions - chemical stability and degradations of drugs - instrumental methods in ADMET - drug metablic processes - routes of administration and excretion of drug - pharmacokinetic/pharmacodynamic study - quantitative structure activity/property relationship - ADME/PK modelling - Toxicology screening - Transporter identification and study