嗜酸性中耳炎的治疗

A. Matsubara, J. Takahata, Tomoya Miura, Naomi Kudo
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引用次数: 3

摘要

嗜酸性中耳炎(EOM)的显著特征是粘性中耳积液(MEE)浸润大量嗜酸性粒细胞。由于外耳炎是进行性听力损失的高风险疾病,因此早期诊断和适当治疗以及了解外耳炎的病理是必不可少的。EOM的治疗策略包括去除富含来自嗜酸性粒细胞的细胞毒性蛋白的高粘性MEE,以及抑制局部和全身嗜酸性粒细胞炎症。在此,我们将具体介绍我科如何治疗急症患者。关于EOM急性期的治疗,局部和/或全身性类固醇已证明其疗效。对于EOM的长期管理,各种抗过敏药物的组合已被证明对嗜酸性粒细胞炎症有效是有益的。在相当数量的EOM病例中,我们已经成功地停止了局部和全身类固醇。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment for Eosinophilic Otitis Media
Eosinophilic Otitis Media (EOM) is remarkably characterized by viscous middle ear effusion (MEE) infiltrated with numerous eosinophils. Since EOM is a high risk disease of progressive hearing loss, early diagnosis and management of appropriate treatment along with an understanding of the pathology of EOM are imperative. The treatment strategies for EOM comprise the removal of the highly viscous MEE enriched with a cytotoxic protein derived from eosinophils, and the suppression of local and systemic eosinophilic inflammation. Here, we introduce how we treat EOM patients in our department concretely. Regarding the management of the acute phase of EOM, topical and/or systemic steroids have proven their efficacy. Regarding the long-term management of EOM, a combination of various antiallergic drugs that have proven efficacy for eosinophilic inflammation is beneficial. In a considerable number of EOM cases, we have succeeded cessation of topical and systemic steroids.
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