老年糖尿病大鼠经过一段时间的高强度间歇训练后,海马Mir146a基因表达增加,血糖、胰岛素和胰岛素抵抗水平降低的研究

Bahman Shamshadi, R. Askari, Rasul Rezaei, Amir Hossein Haghighi, یداشمش نمهب
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引用次数: 0

摘要

microrna已被报道为各种疾病的潜在有价值的生物标志物,包括糖尿病、心脏病、神经系统疾病和与年龄相关的疾病。本研究旨在探讨8周高强度间歇性运动对老年糖尿病雄性大鼠海马mir146a表达、血糖、胰岛素和胰岛素抵抗的影响。方法:选用18 ~ 21月龄雄性Wistar大鼠40只,平均体重280±20 g。采用链脲佐菌素治疗糖尿病后,随机分为4组,1)健康高强度间歇训练(HIIT)运动组,2)健康对照组,3)糖尿病HIIT运动组,4)糖尿病对照组。需要说明的是,每组10只大鼠。锻炼组按照HIIT计划每周锻炼5天,持续8周。采用GraphPad Prism (version 8)软件进行数据分析,P<0.05为显著性水平。结果:结果显示,与糖尿病对照组相比,8周的HIIT运动增加了运动组和运动组mir146a的表达(P<0.001)。此外,与糖尿病对照组相比,糖尿病运动组、健康HIIT运动组和健康对照组的血糖、胰岛素和胰岛素抵抗水平显著降低(P<0.001)。结论:8周的HIIT训练增加了mir146a的表达,减少了海马区神经元的破坏。此外,它可以作为一种合适的非治疗机制,用于糖尿病患者预防或减少与认知能力相关的大脑区域的损伤
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigation of an Increase in the Expression of the Mir146a Gene in The Hippocampus and a Decrease in the Levels of Blood Sugar, Insulin, and Insulin Resistance in Elderly Diabetic Rats after a Period of High-Intensity Interval Training
Introduction: MicroRNAs have been reported as potentially valuable biomarkers for various ‎diseases, including diabetes, heart diseases, neurological diseases, and age-related diseases. The ‎present study aimed to investigate the effect of 8 weeks of intense intermittent exercise on the ‎expression of mir146a, blood sugar, insulin, and insulin resistance in the hippocampus of aged diabetic male rats. Method: This study was performed on 40 male Wistar rats aged 18-21 months with an average weight of ‎‎280±20 g. After becoming diabetic through streptozotocin solution, they were ‎randomly divided into 4 groups, including 1) healthy high-intensity interval training (HIIT) exercise, 2) healthy control, 3) diabetic HIIT exercise, and 4) diabetic control. It should be mentioned that each group included 10 rats. The exercise groups exercised 5 days a week ‎according to the HIIT programs for 8 weeks. The collected data were analyzed using GraphPad Prism software (version 8) at a significance level of P<0.05. Results: The results showed that 8 weeks of HIIT exercise increased the ‎expression of mir146a in both of the exercise groups, compared to the diabetic control ‎group (P<0.001). Moreover, the blood sugar, insulin, and insulin resistance levels significantly decreased in the diabetic exercise, healthy HIIT exercise, ‎‎and healthy control ‎groups, compared to the diabetic control group (P<0.001).‎ Conclusion: It can be concluded that 8 weeks of HIIT training, which increased the expression of mir146a, can reduce neuronal destruction in the hippocampus region. Moreover, it can be used as a suitable non-therapeutic mechanism for diabetics to prevent or reduce damage in this brain region that is related to cognitive abilities
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