Anti-diabetic activity of stem bark of Berberis aristata D.C. in alloxan induced diabetic rats

Object: To evaluate antidiabetic activity of stem bark of Berberis aristata D.C. (Berberdiaceae) in alloxan induced diabetic rats. Materials and Method: Male Wistar albino rats (150–250 g) were taken and study for glucose tolerance test and alloxan induced diabetic rats. The ethanolic extract of B. aristata were selected for antidiabetic activity. Blood glucose levels were estimated in all groups on 1st, 4th, 7th and 15th day of the treatment with B. aristata. The biochemical parameters and body weight were estimated all treated groups and compared against diabetic control group. Results: The ethanolic extract of stem bark of B. aristata showed a significant hyperglycemic effect in alloxan induced diabetic rats. It reduces blood glucose level 60.4% and & 75.46 % at the dose of 25 mg/kg and 50 mg/kg in diabetic rats. B. aristata has a significant antidiabetic activity in glucose tolerance test Conclusion: The results justify the traditional use of bark in the treatment of diabetes.