在超低剂量计算机断层扫描方案中,使用第三代双源CT与超高音高- a幻象研究观察者对肺结节检测的敏感性

Anatomia Pub Date : 2023-01-13 DOI:10.3390/anatomia2010002
Natascha Leitzig, Sonja Janssen, H. Kayed, S. Schönberg, H. Scheffel
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引用次数: 0

摘要

本研究评估了超低剂量计算机断层扫描(ULDCT)对肺结节可检出性的影响。研究了管电流设置、核、第三代迭代重建算法的强度水平和节距的影响。胸部幻象伴不同密度和直径的人造球形结节,采用第三代双源CT检查。扫描和后处理协议,管电流水平,以及超高和非高音调模式应用。使用滤波后的反投影(FBP)或先进的基于模型的迭代重建(钦佩)算法重建图像。使用锐利(Bl57)或中柔(Br36)卷积核。朗读由一个有经验的读者和一个没有经验的读者进行。在管电流为120 mAs和90 mAs时,使用非高音协议,在尖锐核和迭代重建电平为5的情况下,发现了最高的观测器灵敏度。非高音方案对实性结节的检出率较好。使用中软核的组合比使用尖锐核的组合获得了略高的观察者灵敏度。假阳性(FP)更常见于亚实性结节,管电流水平为120 mAs,核尖。无论大小、密度和读取器经验如何,90 mAs的管电流水平结合最高的迭代重建水平在肺结节检测中获得了最高的准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Observer Sensitivity for Detection of Pulmonary Nodules in Ultra-Low Dose Computed Tomography Protocols Using a Third-Generation Dual-Source CT with Ultra-High Pitch—A Phantom Study
This study evaluates ultra-low-dose computed tomography (ULDCT) protocols concerning the detectability of pulmonary nodules. The influence of tube current settings, kernels, strength levels of third-generation iterative reconstruction algorithms, and pitch was investigated. A chest phantom with artificial spherical nodules of different densities and diameters was examined with a third-generation dual-source CT. Scanning and post-processing protocols, tube current levels, and ultra-high and non-high pitch modes were applied. Images were reconstructed with filtered back-projection (FBP) or advanced model-based iterative reconstruction (ADMIRE) algorithms. Sharp (Bl57) or medium-soft (Br36) convolution kernels were applied. The reading was performed by an experienced and an inexperienced reader. The highest observer sensitivity was found using a non-high pitch protocol at tube currents of 120 mAs and 90 mAs with the sharp kernel and iterative reconstruction level of 5. Non-high pitch protocols showed better detectability of solid nodules. Combinations with the medium-soft kernel achieved slightly higher observer sensitivity than with the sharp kernel. False positives (FP) occurred more often for subsolid nodules, at a tube current level of 120 mAs, and with the sharp kernel. A tube current level of 90 mAs combined with the highest iterative reconstruction level achieved the highest accuracy in lung nodule detection regardless of size, density, and reader experience.
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