{"title":"他莫昔芬与吡喹酮治疗实验性感染白化小鼠曼氏血吸虫病的比较","authors":"A. Hafez, A. Mohamed, M. Shakra","doi":"10.21608/jesp.2023.312097","DOIUrl":null,"url":null,"abstract":"Schistosomiasis is blood-dwelling parasites of the genus Schistosoma , mainly S. mansoni, S. japonicum and S. haematobium. Praziquantel ® (PZQ) is the drug of choice for treatment but, its efficacy decreased as drug resistant strains emerged due to widespread usages. This study assessed the in-vivo anti-schistosomal effects of Tamoxifen ® (TAM) compared to praziquantel on experimental S. mansoni-infected mice regarding worm burden, liver enzymes status, cytokines change, histopathological study and the activities of some antioxidants. Mice were infected by ~80±10 cercariae followed by a single oral dose with either praziquantel or tamoxifen 42 days post-infection. The treated mice showed a reduction in worm burden, a decrease in egg load in liver and intestine, a decrease in levels of AST, ALT, interferon-gamma, interleukin 4, and interleukin 10 but, with a significant activities increase of superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GPx) and Catalase (CAT) and decrease in granuloma size than infected non-treated mice.","PeriodicalId":17289,"journal":{"name":"Journal of the Egyptian Society of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"TAMOXIFEN VERSUS PRAZIQUANTEL IN TREATING SCHISTOSOMIASIS MANSONI IN EXPERIMENTAL INFECTED ALBINO MICE\",\"authors\":\"A. Hafez, A. Mohamed, M. Shakra\",\"doi\":\"10.21608/jesp.2023.312097\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Schistosomiasis is blood-dwelling parasites of the genus Schistosoma , mainly S. mansoni, S. japonicum and S. haematobium. Praziquantel ® (PZQ) is the drug of choice for treatment but, its efficacy decreased as drug resistant strains emerged due to widespread usages. This study assessed the in-vivo anti-schistosomal effects of Tamoxifen ® (TAM) compared to praziquantel on experimental S. mansoni-infected mice regarding worm burden, liver enzymes status, cytokines change, histopathological study and the activities of some antioxidants. Mice were infected by ~80±10 cercariae followed by a single oral dose with either praziquantel or tamoxifen 42 days post-infection. The treated mice showed a reduction in worm burden, a decrease in egg load in liver and intestine, a decrease in levels of AST, ALT, interferon-gamma, interleukin 4, and interleukin 10 but, with a significant activities increase of superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GPx) and Catalase (CAT) and decrease in granuloma size than infected non-treated mice.\",\"PeriodicalId\":17289,\"journal\":{\"name\":\"Journal of the Egyptian Society of Parasitology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Egyptian Society of Parasitology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/jesp.2023.312097\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Egyptian Society of Parasitology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/jesp.2023.312097","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
TAMOXIFEN VERSUS PRAZIQUANTEL IN TREATING SCHISTOSOMIASIS MANSONI IN EXPERIMENTAL INFECTED ALBINO MICE
Schistosomiasis is blood-dwelling parasites of the genus Schistosoma , mainly S. mansoni, S. japonicum and S. haematobium. Praziquantel ® (PZQ) is the drug of choice for treatment but, its efficacy decreased as drug resistant strains emerged due to widespread usages. This study assessed the in-vivo anti-schistosomal effects of Tamoxifen ® (TAM) compared to praziquantel on experimental S. mansoni-infected mice regarding worm burden, liver enzymes status, cytokines change, histopathological study and the activities of some antioxidants. Mice were infected by ~80±10 cercariae followed by a single oral dose with either praziquantel or tamoxifen 42 days post-infection. The treated mice showed a reduction in worm burden, a decrease in egg load in liver and intestine, a decrease in levels of AST, ALT, interferon-gamma, interleukin 4, and interleukin 10 but, with a significant activities increase of superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GPx) and Catalase (CAT) and decrease in granuloma size than infected non-treated mice.
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