伊拉克南部Thi-Qar省带状疱疹患者IL-4、IL-12和IL-17水平及其他免疫学特征的估计

Ihsan Rashad
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摘要

潜伏在背根神经节或脑神经中的水痘带状疱疹病毒(VZV)重新激活,产生病毒性疾病带状疱疹。免疫衰老,包括记录的细胞介导的免疫力随着年龄的增长而下降,可导致VZV的再激活。虽然HZ在年轻人中通常是轻微的,但健康状况良好的人,而老年人更容易出现并发症。本研究于2022年7月至2023年1月在Thi-Qar省进行,我们检测了70名没有重复感染的HZ患者血液中VZV IgG抗体、IL-4、IL-12、IL-17的水平,并检查了VTN水平。30名年龄相仿、健康且无感染性和炎症性疾病的人组成了对照组。采集他们的血液样本,通过ELISA系统进行检测。与对照组相比,HZ患者血浆玻璃体粘连蛋白水平下降,血清细胞因子IL-4、IL-12、IL-17水平及VZV IgG抗体滴度均明显升高。结果显示,无慢性疾病的HZ患者IL-17水平明显较高。与患有慢性疾病的人相比。此外,IL-12水平在女性中明显高于男性。研究中没有发现年龄和性别差异有显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Estimation levels of (IL-4, IL-12, and IL-17) and other immunological characteristics in Herpes zoster patients in the southern Iraqi \province of Thi-Qar
Varicella-zoster virus (VZV), which was dormant in the dorsal root ganglia or cranial nerve, reactivates to produce the viral illness shingle. Immunosenescence, which includes the documented decline of cell-mediated immunity with aging, can result in in the VZV reactivation. While HZ is typically mild in young, persons who are in good health, while older individuals are more likely to experience complications. The present study was carried out during the months of July 2022 to January 2023 in the governorate of Thi-Qar We examined the levels of VZV IgG antibodies, IL-4, IL-12,IL-17 and checking level VTN in the blood of 70 HZ patients who did not suffer from superinfection. 30 individuals of a comparable age who were healthy and free of infectious and inflammatory diseases made up the control group. blood samples were collected from them and examined via the ELISA system. While the plasma vitronectin level dropped in HZ patients when in comparison to the control group, both the serum levels of the cytokines IL-4, IL-12, and IL-17 as well as the VZV IgG antibody titer considerably rose. According to the results, HZ patients without chronic illnesses had significantly greater levels of IL-17. compared to individuals suffering from chronic illnesses. Additionally, IL-12 levels were noticeably higher in females than in males. Age and sex differences were not found to be significantly different in the research.
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